CAS 80-49-9 HOMATROPINE METHYL BROMIDE | Products & Prices & Suppliersts

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.target： mAChRIC 50: WKY-E(162.5 nM), SHR-E(170.4nM )In vitro: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.In vivo: : Pre-treatment with homatropine (20 m

Homatropine methylbromide is an organic bromide salt and an azabicycloalkane. It has a role as a muscarinic antagonist, an anti-ulcer drug and an antispasmodic drug.|Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.

ldentification

: Cas NO.: 80-49-9; CID: 6646; Mw: 370.287; MF: C17H24BrNO3; Name:HOMATROPINE METHYL BROMIDE (Related Reference); Synonyms: (1R,3R,5S)-3-{[(2S)-2-hydroxy-2-phenylacetyl]oxy}-8,8-dimethyl-8-azabicyclo[3.2.1]octan-8-ium bromide; (3-endo)-3-{[(2R)-2-Hydroxy-2-phenylacetyl]oxy}-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide;; EINECS: 201-284-0

Safety Data

: [Risk Codes] R20/21/22:Harmful by inhalation, in contact with skin and if swallowed; [Safety Statements] S22:Do not breathe dust S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S36:Wear suitable protective clothing; Hazard Symbols: HazardClass: 6.1

Properties

: Appearance:White to Almost white powder to crystal; Molecular Weight:370.287; Density:1.21; Boiling Point:403.3°C at 760 mmHg; Melting Point:192°C; Flash Point:197.7°C; Refractive index:1.588; Solubility:Freely soluble in water, soluble in ethanol 96 per cent; More Properties>>

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