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1-Chlorobutane structure

1-Chlorobutane
1-Chlorobutane is used as an intermediate for the production of other chemicals in the chemical industry.1-chlorobutane is a common extraction solvent in the forensic toxicology arena. A benefit of 1-chlorobutane is that it is less dense than water and therefore settles above the aqueous layer.As butylating agent in organic synthesis, e.g., in the manufacture of butyl cellulose.1-chlorobutane will be halogenated to produce dichlorobutane using sulfuryl chloride via a free-radical chain reaction mechanism. View more+
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1. Names and Identifiers
1.1 Name
1-Chlorobutane
1.2 Synonyms
1-butyl chloride; 1-chloro-butane; 1-CHLOROBUTANE FOR PROTEIN SEQUENCE &; 1-CHLOROBUTANE FOR UV-SPECTROSCOPY &; 1-CHLOROBUTANE 'B&J BRAND' 1 L; 1-chloroethane; Butane,1-chloro; butyl chloride; Chlorobutane,1; Chlorure de butyle; Cough. Sore throat. Drowsiness. Redness. Dry skin. Redness.; EINECS 203-696-6; MFCD00001009; NBC wormer; N-BUTYL CHLORIDE; N-Propylcarbinyl chloride; Sure Shot;
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1.3 CAS No.
109-69-3
1.4 CID
8005
1.5 EINECS
203-696-6
1.6 Molecular Formula
C4H9Cl
1.7 Inchi
InChI=1S/C4H9Cl/c1-2-3-4-5/h2-4H2,1H3
1.8 InChkey
VFWCMGCRMGJXDK-UHFFFAOYSA-N
1.9 Canonical Smiles
CCCCCl
1.10 Isomers Smiles
CCCCCl
2. Properties
2.1 Vapour pressure
Relative vapour density (air = 1): 3.2
2.2 Solubility
0.5 g/L (20 oC)
2.3 Viscosity
0.0045 POISE @ 20 °C
2.4 VaporDensity
Relative vapour density (air = 1): 3.2
2.5 Appearance
Butyl chloride appears as a water white liquid with a sharp odor. Flash point 20°F. Boiling point 77-78°C (173°F). Density 7.5 lb / gal. Slightly soluble in water. Vapors are heavier than air. Used in the manufacture of a variety of organic chemicals.
2.6 Atmospheric OH Rate Constant
1.50e-12 cm3/molecule*sec
2.7 Storage
Ambient temperatures.
2.8 Autoignition Temperature
860 °F (USCG, 1999)
2.9 Color/Form
COLORLESS LIQ
2.10 Decomposition
Dangerous; when heated to decomposition, emits highly toxic fumes of phosgene.
2.11 Heat of Vaporization
30.39 KJ/mol
2.12 HenrysLawConstant
0.02 atm-m3/mole
2.13 Odor
Unpleasant
2.14 Odor Threshold
Odor low: 3.3352 mg/cu m; Odor high: 6.3293 mg/cu m
2.15 Water Solubility
water: soluble 0.11g/L at 20°C
2.16 Spectral Properties
Index of refraction: 1.40223 @ 20 deg C/D
IR: 5640 (Coblentz Society Spectral Collection)
NMR: 6763 (Sadtler Research Laboratories Spectral Collection)
MASS: 187 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
2.17 Stability
Stable. Highly flammable. Note low flash point and wide explosion limit range. Incompatible with strong oxidizing agents, strong bases.
2.18 StorageTemp
2-8°C
3. Use and Manufacturing
3.1 Description

1-Chlorobutane is a highly flammable, clear, colorless liquid at standard temperature and pressure. The density is 0.886 g/cm3, which is lower than that of water. It does not react with water, is classified as highly flammable, but it is neither an oxidizer nor an explosive. However, vapors can form explosive mixtures with air. The substance self-ignites at 245℃.A water white liquid with a sharp odor. Flash point 20°F. Boiling point 77-78°C (173°F). Density 7.5 lb / gal. Slightly soluble in


Butyl chloride appears as a water white liquid with a sharp odor. Flash point 20°F. Boiling point 77-78°C (173°F). Density 7.5 lb / gal. Slightly soluble in water. Vapors are heavier than air. Used in the manufacture of a variety of organic chemicals.|Liquid|COLOURLESS LIQUID WITH PUNGENT ODOUR.


Butyl chloride appears as a water white liquid with a sharp odor. Flash point 20°F. Boiling point 77-78°C (173°F). Density 7.5 lb / gal. Slightly soluble in water. Vapors are heavier than air. Used in the manufacture of a variety of organic chemicals.

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3.2 Methods of Manufacturing
IRRADIATION OF ETHYLENE AND HYDROGEN CHLORIDE WITH COBALT 60|PREPD FROM N-BUTYL ALC BY HEATING WITH HYDROCHLORIC ACID & ANHYDROUS ZINC CHLORIDE.
3.3 Potential Exposure
Butyl chloride is used as a solvent; asa medicine to control worms, and to make other chemicals
3.4 Purification Methods
Shake it repeatedly with conc H2SO4 (until no further colour develops in the acid), then wash it with water, aqueous NaHCO3 or Na2CO3, and more water. Dry it with CaCl2, or MgSO4 (then with P2O5 if desired), decant and fractionally distil it. Alternatively, a stream of oxygen continuing ca three times as long as is necessary to obtain the first coloration of starch iodide paper by the exit gas. After washing with NaHCO3 solution to hydrolyse ozonides and to remove the resulting organic acid, the liquid is dried and distilled [Chien & Willard J Am Chem Soc 75 6160 1953]. [Beilstein 1 IV 246.]
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3.5 Usage
1-Chlorobutane is used as an intermediate for the production of other chemicals in the chemical industry.1-chlorobutane is a common extraction solvent in the forensic toxicology arena. A benefit of 1-chlorobutane is that it is less dense than water and therefore settles above the aqueous layer.As butylating agent in organic synthesis, e.g., in the manufacture of butyl cellulose.1-chlorobutane will be halogenated to produce dichlorobutane using sulfuryl chloride via a free-radical chain reaction mechanism.
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3.6 Waste Disposal
Dissolve or mix the materialwith a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal,state, and local environmental regulations must beobserved. 1-Chlorobutane Preparation Products And Raw materials Preparation Products
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4. Safety and Handling
4.1 Exposure Standards and Regulations
Specification and dosage requirements for n-butyl chloride are given in detail for the removal of ascarids and hookworms in dogs, puppies, cats, and kittens.
4.2 Octanol/Water Partition Coefficient
log Kow= 2.39
4.3 Fire Hazard
Special Hazards of Combustion Products: May produce phosgene gas in fire
4.4 Other Preventative Measures
If material /is/ not on fire and not involved in /a/ fire keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.
Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
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4.5 DOT Emergency Guidelines
/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.
/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Evacuation: Large spill: Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Fire: CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. Small fires: Dry chemical, CO2, water spray or regular foam. Large fires: Water spray, fog or regular foam. Do not use straight streams. Move containers from fire area if you can do it without risk. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
/GUIDE 130: FLAMMABLE LIQUIDS (NON-POLAR/WATER-IMMISCIBLE/NOXIOUS)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
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4.6 Fire Fighting Procedures
To fight fire: Foam, carbon dioxide, dry chemical.
If material /is/ on fire or involved in /a/ fire do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemial or carbon dioxide.
If fire becomes uncontrollable or container is exposed to direct flame-consider evacuation of one-third (1/3) mile radius.
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4.7 FirePotential
FLAMMABLE, DANGEROUS FIRE RISK.
4.8 Safety Profile
Moderately toxic by ingestion. Mutation data reported. See CHLORINATED HYDROCARBONS, ALIPHATIC. Skin and eye irritant. Dangerous fire hazard when exposed to heat or flame. Moderately explosive when exposed to flame. When heated to decomposition it emits hghly toxic fumes of phosgene and Cl-. To fight fire, use foam, COa, dry chemical. Incompatible with oxidizing materials
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4.9 Formulations/Preparations
GRADES: NF; TECHNICAL.
4.10 Incompatibilities
Vapor may form explosive mixture withair. May accumulate static electrical charges, and maycause ignition of its vapors. Water contact slowly formshydrochloric acid. Incompatible with oxidizers (chlorates,nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,strong acids, oxoacids, epoxides, alkaline earth, and alkalimetals; finely divided metal. Attacks metals in presence ofmoisture. Attacks some plastics, rubber, or coatings
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4.11 Protective Equipment and Clothing
Skin, eye irritant
4.12 Skin, Eye, and Respiratory Irritations
Skin, eye irritant
4.13 Toxicity
LD50 orally in rats: 2.67 g/kg (Smyth)
5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H225 Highly flammable liquid and vapour
Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum
13C NMR : in CDCl3  
1H NMR : parameter neat  
IR : CCl4 solution  
IR : liquid film  
Mass  
7. Synthesis Route
109-69-3Total: 143 Synthesis Route
 
71-36-3
71-36-3 61 Suppliers
 
109-69-3
109-69-3 148 Suppliers
 
75-03-6
75-03-6 71 Suppliers
 
109-69-3
109-69-3 148 Suppliers
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8. Precursor and Product
precursor:
78-83-1
78-83-1
75-03-6
75-03-6
71-36-3
71-36-3
product:
542-69-8
542-69-8
629-45-8
629-45-8
109-79-5
109-79-5
616-21-7
616-21-7
109-72-8
109-72-8
109-73-9
109-73-9
111-92-2
111-92-2
544-40-1
544-40-1
110-59-8
110-59-8
627-05-4
627-05-4
9. Computed Properties
10.Other Information
Usage
1-Chlorobutane is used as intermediates and solvents. It is used for HPLC, spectrophotometry and environmental testing. It is used as an alkylating reagent in organic and organometallic compound synthesis. It is also employed as an anthelmintic in veterinary medicine.
Usage
1-Chlorobutane is used as intermediates and solvents. It is used for HPLC, spectrophotometry and environmental testing. It is used as alkylating reagent in organic and organometallic compound synthesis. It is also employed as an antihelmintic in veterinary medicine.
Storage Conditions
IRRADIATION OF ETHYLENE AND HYDROGEN CHLORIDE WITH COBALT 60|PREPD FROM N-BUTYL ALC BY HEATING WITH HYDROCHLORIC ACID & ANHYDROUS ZINC CHLORIDE.
Henrys Law Constant
0.02 atm-m3/mole
Experimental Properties
1 GAL WEIGHS 7.35 LB; DIPOLE MOMENT: 1.95
Reactive Group
Halogenated Organic Compounds
Reactivity Profile
BUTYL CHLORIDE is incompatible with oxidizing agents and strong bases. Reacts with aluminum powder, magnesium, liquid oxygen, potassium and sodium (NTP, 1992). Emits phosgene gas when heated to decomposition. May be sensitive to heat.
Autoignition Temperature
860 °F (USCG, 1999)|860 °F (460 °C)|245 °C
Physical Dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.
Storage features
Fireproof. Separated from incompatible materials. See Chemical Dangers. Well closed.
FDA Requirements
Specification and dosage requirements for n-butyl chloride are given in detail for the removal of ascarids and hookworms in dogs, puppies, cats, and kittens.
Special Reports
DHHS/NTP; Toxicology & Carcinogenesis Studies of n-Butyl Chloride in F344/N Rats and B6C3F1 Mice Technical Report Series No. 312 (1986) NIH Publication No. 86-2568
Fire Hazards
Special Hazards of Combustion Products: May produce phosgene gas in fire (USCG, 1999)|Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.|Flammable - 3rd degree
Nonfire Spill Response
Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)
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Personal Protective Equipment
Approved respirator, chemical safety goggles, rubber gloves, other protective clothing. (USCG, 1999)
Fire Potential
FLAMMABLE, DANGEROUS FIRE RISK.
Fire Fighting Procedures
To fight fire: Foam, carbon dioxide, dry chemical.|If material /is/ on fire or involved in /a/ fire do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemial or carbon dioxide.|If fire becomes uncontrollable or container is exposed to direct flame-consider evacuation of one-third (1/3) mile radius.
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Preventive Measures
If material /is/ not on fire and not involved in /a/ fire keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.|Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.|If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
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Spillage Disposal
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Do NOT let this chemical enter the environment.
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Safe Storage
Fireproof. Separated from incompatible materials. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. See Chemical Dangers.
Inhalation Risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C , especially on spraying.
Effects Of Short Term Exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system.
Fire Prevention
NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling.
Exposure Prevention
PREVENT GENERATION OF MISTS!
Inhalation Prevention
Use ventilation, local exhaust or breathing protection.
Skin Prevention
Protective gloves.
Eye Pprevention
Wear safety spectacles or eye protection in combination with breathing protection.
Pollution Sources
n-Butyl chloride is used as a solvent, an alkylating agent, and an antihelmintic medicine(2). It may be released to the environment in emissions or wastewater related to its manufacture and these uses. n-Butyl chloride was formed during the chlorination of leachate obtained from a simulated landfill used to study the codisposal of metal plating sludge with municipal solid waste(1).
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Environmental Fate
TERRESTRIAL FATE: n-Butyl chloride has a very high vapor pressure, 100 mm Hg at 25 °C(1), indicating that volatilization from soil will be rapid and a primary removal process. It has an estimated low adsorptivity to soil (Koc = 93-102)(1-2) and therefore would be mobile in soil. Biodegradation in soil is unknown(SRC).|AQUATIC FATE: If released in water, n-butyl chloride will be lost rapidly by volatilization. Its estimated volatilization half-life in a model river and pond are 2.9 hr(1-2) and 34 hr(3), respectively. In groundwater, where volatilization may not occur, n-butyl chloride may be lost by hydrolysis. Based upon hydrolysis rates for alkyl chlorides, the half-life is estimated to be between 6 hr and 38 days at neutral pH(4). The half-life at higher pHs will be shorter. Photodegradation, adsorption to sediment, and bioconcentration in fish are not important aquatic fate processes(SRC).|ATMOSPHERIC FATE: n-Butyl chloride will degrade via reaction with photochemically produced hydroxyl radicals in the atmosphere. The half-life of n-butyl chloride in the atmosphere is estimated to be 7.0 days(1). n-Butyl chloride does not absorb radiation >290 nm and therefore it will not directly photolyze(2). Due to its water solubility, 1100 mg/l(3), washout by rain should occur. However, n-butyl chloride removed in this manner will revolatilize into the atmosphere(SRC).|Maximum permissible concentrations in open waters are 0.004 mg/l.
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Abiotic Degradation
Alkyl halides hydrolyze in water by neutral and base catalyzed reactions to give the corresponding alcohols; no acid catalyzed processes have been reported(2). No rate for neutral hydrolysis of n-butyl chloride is available. Based on extrapolations of hydrolysis rates of analogous compounds determined at higher temperatures and generalizations concerning the relative reactivity of analogs, the hydrolysis half-life of n-butyl chloride at 25 °C is estimated to lie in the range of 6 hr to 38 days(2). In the atmosphere, n-butyl chloride will react with photchemically produced hydroxyl radicals by H-atom extraction. The estimated rate of reaction is 2.29X10-12 cu cm/molec-sec(3). Assuming a hydroxyl radical concentration of 5X10+5 per cu cm, the half-life of n-butyl chloride in the atmosphere is 7.0 days. n-Butyl chloride does not absorb radiation >290 nm and therefore it will not directly photolyze(4). The half-life of n-butyl chloride in an eutrophic lake due to the photochemical production of hydroxyl radicals in full summer noon sunlight is 1000 hr(1). Therefore, this reaction would not be a significant degradation route for n-butyl chloride in surface waters(SRC).
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Bioconcentration
16.98|Using the log octanol/water partition coefficient for n-butyl chloride, 2.64(1), one estimates a BCF of 60 using a recommended regression equation(2,SRC). Therefore, n-butyl chloride will not bioconcentrate in fish and aquatic organisms(2)
Mobility
Using the water solubility for n-butyl chloride, 1100 mg/l(1), the Koc can be estimated to be 93 and 102 using two recommended regression equations(2,SRC). These estimates indicate that n-butyl chloride will have high mobility in soil(3).
Volatilization
Based on a Henry's Law constant of 0.0167 atm-cu m/mol(1), the volatilization of n-butyl chloride from a model river 1 m deep, flowing at 1 m/sec with a 3 m/sec wind is 2.9 hr(2). The volatilization half-life from a model pond is 34 hr(3). Due to its high vapor pressure and Henry's Law constant and low adsorptivity to soil, n-butyl chloride should volatilize rapidly from dry and moist soils(SRC).
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Human Exposure
Exposure to n-butyl chloride is primarily in the workplace. Probable routes occupational exposure are inhalation and dermal contact. (SRC)|NIOSH (NOES Survey 1981-1983) has statistically estimated that 3,201 workers are exposed to n-butyl chloride in the USA(1).
Therapeutic Uses
MEDICATION (VET): ANTHELMINTIC FOR TREATMENT OF ROUND- & TAPEWORMS IN DOGS ...|MEDICATION (VET): Anthelmintic
Biological Half Life
0.35 Days
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)


Fresh air, rest. Refer for medical attention.


Remove contaminated clothes. Rinse and then wash skin with water and soap.


First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

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Human Toxicity Excerpts
TOXIC ON PROLONGED INHALATION.|WEAKER CENTRAL NERVOUS DEPRESSANT ACTIONS THAN ETHYL CHLORIDE.
Mesh Entry Terms
1-chlorobutane
Symptoms

Cough. Sore throat. Drowsiness.


Redness. Dry skin.


Redness.

Production
1,000,000 - 10,000,000 lb|(1977) PROBABLY GREATER THAN 4.54X10+6 GRAMS|(1979) PROBABLY GREATER THAN 4.54X10+6 GRAMS
Formulations
GRADES: NF; TECHNICAL.
Manufacturing Info
All other basic organic chemical manufacturing|Butane, 1-chloro-: ACTIVE
Use Classification
Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Fire Hazards -> Flammable - 3rd degree
11. Toltal 127 Suppliers View more
1-chlorobutane with high quality cas 109-69-3
Hebei Crovell Biotech Co. Ltd
 1YR   China
Tel: Update Time:2024/11/15
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Supply clear liquid of 99.5% 1-chlorobutane / n-butyl chloride/ CAS No.:109-69-3
Hebei Yanxi Chemical Co.,Ltd
 1YR   China
Tel: Update Time:2024/11/14
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1-CHLOROBUTANE 'B&J BRAND' 1 L
Hebei Saisier Technology Co., LTD
 1YR   China
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1-Chlorobutane
Hangzhou Utanpharma biology co,.Ltd
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1-Chlorobutane
Henan Tianfu Chemical Co.,Ltd
 1YR   China
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12. Related Questions
How is 1-Chlorobutane synthesized?Introduction 1-Chlorobutane is an important fine chemical product. In industry, it is usually prepared by reacting alcohols with different chlorinating agents, such as concentrated hydrochloric acid, ..
What is the difference between saying butyl chloride and chlorobutyl?The difference is as follows. Below are the structures of compounds that can be called butyl chlorides. You did not specify which butyl chloride so I have drawn all four. So, this is what ‘butyl chlo..
Which is SN1 and which one SN2 and why? A. n-butyl chloride with CN- B. benzyl chloride with CN- and write the reaction for each oneNucleophilic Substitution Reaction of n-butyl chloride follows SN1 mechanistic pathway when the carbocation formed after the removal of leaving group is stable. A. n - butyl carbocation is a primary c..
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4. Safety and Handling
5. Msds
6. NMR Spectrum
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