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2,2-Dimethoxypropane

CAS：77-76-9
MW:104.14758
MF：C5H12O2

2,2-Dimethoxypropane(DMP) is used in histology and considered to be more efficient than ethanol for the dehydration of animal tissue. 2,2-Dimethoxypropane Preparation Products And Raw materials Preparation Products View more+

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Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
NMR Spectrum
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: 2,2-Dimethoxypropane

1.2 Synonyms: 2,2-Dimethyoxypropane; ACETONE DIMETHYL ACETAL; ACETONE DIMETHYL KETAL; acetone dimethylacetal; Acetone-dimethyl acetal; C.I. 77769; Dimolybdenum trioxide; EINECS 201-056-0; MFCD00008479; Molybdenum oxide (Mo2O3); Propane, 2,2-dimethoxy-; Propane,2,2-dimethoxy-;

1.3 CAS No.: 77-76-9

1.4 CID: 6495

1.5 EINECS: 201-056-0

1.6 Molecular Formula: C5H12O2

1.7 Inchi: InChI=1S/C5H12O2/c1-5(2,6-3)7-4/h1-4H3

1.8 InChkey: HEWZVZIVELJPQZ-UHFFFAOYSA-N

1.9 Canonical Smiles: CC(C)(OC)OC

1.10 Isomers Smiles: CC(C)(OC)OC

2. Properties

2.1 Vapour pressure: 3.59 (vs air)

2.2 Solubility: 180g/l

2.3 VaporDensity: 3.59 (vs air)

2.4 Appearance: Clear colorless Liquid

2.5 Atmospheric OH Rate Constant: 3.92e-12 cm3/molecule*sec

2.6 Storage: Ambient temperatures.

2.7 Chemical Properties: colourless liquid

2.8 Color/Form: Clear colorless

2.9 Water Solubility: H2O: 18 g/100 mL (25 oC)

2.10 Stability: Stable. Highly flammable - note low flash point. Vapour may form an explosive mixture with air. May form explosive peroxides when exposed to air. Incompatible with strong oxidizing agents.

2.11 StorageTemp: Store below +30°C.

3. Use and Manufacturing

3.1 Description

colourless liquid

2,2-Dimethoxypropane or acetone dimethyl acetal or DMP is an organic compound and an alkylating reagent. The chemical formula is C5H12O2 and the molecular formula is (CH3)2C(OCH3)2. It is the acetalisation product of acetone and methanol. Dimethoxypropane is an intermediate for the synthesis of 2-methoxypropene. In histology, DMP is now considered to be more efficient than ethanol for the dehydration of animal tissue.

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3.2 Usage: 2,2-Dimethoxypropane(DMP) is used in histology and considered to be more efficient than ethanol for the dehydration of animal tissue. 2,2-Dimethoxypropane Preparation Products And Raw materials Preparation Products

4. Safety and Handling

4.1 Safety: A very dangerous fire hazard when exposed to heat, flame or oxidizers. When heated to 210°C it burns with a cool flame and then explodes. Explosive reaction with metal perchlorates (e.g., manganese(II) perchlorate; nickel(II) perchlorate) above 65°C. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes? F,Xi
Risk Statements? 11-36-36/37/38?
R11:Highly flammable.?
R36:Irritating to eyes.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements? 26-9-37/39-33-16-33,37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S9:Keep container in a well-ventilated place.?
S37/39:Wear suitable gloves and eye/face protection.?
S33:Take precautionary measures against static discharges.?
S16:Keep away from sources of ignition.?
S37/39:Wear suitable gloves and eye/face protection.
RIDADR? UN 1993 3/PG 2
WGK Germany? 2
F? 10-21
HazardClass? 3
PackingGroup? II
HS Code? 29110000

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4.2 Specification: ?2,2-Dimethoxypropane , its CAS NO. is 77-76-9, the synonyms are Acetone dimethyl acetal ; Acetone dimethyl ketal ; Propane, 2,2-dimethoxy- .

4.3 Toxicity: LD50 orally in Rabbit: > 2260 mg/kg LD50 dermal Rat > 2100 mg/kg

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 2

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Precautionary statement(s)
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

13C NMR : in CDCl3

1H NMR : parameter in CDCl3

IR : CCl4 solution

IR : liquid film

Raman : 4880 A,200 M,liquid

Mass

7. Synthesis Route

77-76-9Total: 33 Synthesis Route

58-56-0 268 Suppliers

948-00-5

77-76-9 170 Suppliers

29328-23-2

77-76-9 170 Suppliers

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8. Precursor and Product

precursor:

58-56-0

90593-00-3

97581-38-9

29328-23-2

74-99-7

149-73-5

125977-47-1

67-56-1

product:

3330-23-2

78371-05-8

75-30-9

598-53-8

51268-87-2

50622-09-8

1707-77-3

7217-26-7

22961-82-6

116-11-0

9. Computed Properties

Molecular Weight：104.14758g/mol
Molecular Formula：C₅H₁₂O₂
Compound Is Canonicalized：True
Exact Mass：0.6
XLogP3-AA：104.083729621
Monoisotopic Mass：104.083729621
Complexity：44
Rotatable Bond Count：2
Hydrogen Bond Donor Count：0
Hydrogen Bond Acceptor Count：2
Topological Polar Surface Area：18.5
Heavy Atom Count：：7
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADccBgMAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGgAAAAAACASAgAICCAAABAAAAAAAAAAAAAAAAAAAAAAAAAAQAAAAAAAgAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10.Other Information

Usage: 2,2-Dimethoxypropane acts as a dehydrating agent. It also serves as an intermediate in the synthesis of vitamin E, vitamin A and various carotenoids such as astaxanthin. It is used as a reagent for the preparation of 1,2-diols, acetonides, isopropylidene derivatives of sugars, nucleosides, methyl esters of amino acids and enol ethers.

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BRN: 635678

Chemical Properties: colourless liquid

Uses: 2,2-Dimethoxypropane(DMP) is used in histology and considered to be more efficient than ethanol for the dehydration of animal tissue.

General Description: 2,2-Dimethoxypropane is an organic compound, which may be used as a protecting agent in the process of the synthesis of structurally related alkaloids like narciclasine and lycoricidine using phenylbromide as the starting material.

Mesh Entry Terms: 2,2-dimethoxypropane

Manufacturing Info: Propane, 2,2-dimethoxy-: ACTIVE

11. Toltal 158 Suppliers View more

Hebei Yanxi Chemical Co.,Ltd

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Hebei Crovell Biotech Co. Ltd

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Hangzhou Utanpharma biology co,.Ltd

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Jinlan Pharm-Drugs Technology Co., Limited

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12. Related Questions

: What are the applications of 2,2-Dimethoxypropane?2,2-Dimethoxypropane has various applications in the preparation of acetal, acetone compounds, isopropyl derivatives, amino acid esters, and enol ethers. It is also used in the synthesis of phosphate ..; Introduction of 2,2-DimethoxypropaneFormation of Acetals. The reagent can be used to prepare a variety of acetals via transacetalization. This involves interchanging the alkoxy or ketone groups in an acidic medium. Both symmetrical [R1R..; What is 2,2-Dimethoxypropane and its Applications? 【中文名称】 2,2-Dimethoxypropane 【英文名称】2,2-Dimethoxypropane 【分子式】C5H12O2 【分子量】104.15 【CAS登录号】[77-76-9] 【缩写和别名】Acetone Dimethyl Acetal 【结构式】【物理性质】2,2-Dimethoxy..

13. Realated Product Infomation