Encyclopedia / Agrochemical Intermediates / Pharmaceutical Intermediates / Organic Intermediate

2,4-Difluoroaniline

CAS：367-25-9
MW:129.11
MF：C6H5F2N

2,4-difluoroaniline is an important intermediate used in organic synthesis, pharmaceuticals agrochemicals, dyes, and agricultural chemicals.

Email Tweet Share

Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
NMR Spectrum
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: 2,4-Difluoroaniline

1.2 Synonyms: 1-amino-2,4-difluorobenzene; 2,4,6-TRIFLUOROPHENYL ISOCYANATE; 2,4-DIFLOUROANILINE; 2,4-Difluoranilin; 2,4-difluoro-anilin; 2,4-Difluoro-aniline; 2,4-DIFLUOROBENZENAMINE; 2,4-difluorobenzeneamine; 2,4-DIFLUOROPHENYLAMINE; 2,4-DIFLUROANILINE; 2,4-fluoroaniline; 4-Difluoroaniline; 4-fluoro-2-fluoroaniline; AKOS 91127; Aniline, 2,4-difluoro-; Aniline,2,4-difluoro; Benzenamine, 2,4-difluoro-; Difluoroaniline; EINECS 206-687-5; LABOTEST-BB LTBB000653; MFCD00007648; NSC 10297;

View all

1.3 CAS No.: 367-25-9

1.4 CID: 9709

1.5 EINECS: 206-687-5

1.6 Molecular Formula: C6H5F2N

1.7 Inchi: InChI=1S/C6H5F2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2

1.8 InChkey: CEPCPXLLFXPZGW-UHFFFAOYSA-N

1.9 Canonical Smiles: C1=CC(=C(C=C1F)F)N

1.10 Isomers Smiles: C1=CC(=C(C=C1F)F)N

2. Properties

2.1 Solubility: Not miscible or difficult to mix.

2.2 Appearance: Clear brown Liquid

2.3 Storage: Ambient temperatures.

2.4 Chemical Properties: dark red liquid

2.5 Color/Form: Clear brown

2.6 Physical: PHYSICAL DESCRIPTION: Dark reddish-purple liquid. (NTP, 1992)

2.7 pKa: 3.26±0.10(Predicted)

2.8 Water Solubility: H2O: 1-5 g/100 mL at 20.55 oC;Not miscible or difficult to mix.

2.9 Stability: Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.

2.10 StorageTemp: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

3. Use and Manufacturing

3.1 Description

dark red liquid

2,4-difluoroaniline is a dark reddish-purple liquid. (NTP, 1992)

3.2 General Description: Dark reddish-purple liquid.

3.3 GHS Classification: Signal: Danger
GHS Hazard Statements
Aggregated GHS information provided by 35 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (97.14%): Harmful if swallowed [Warning Acute toxicity, oral]
H311 (94.29%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (17.14%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H331 (85.71%): Toxic if inhaled [Danger Acute toxicity, inhalation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501

View all

3.4 Methods of Manufacturing: 1.2, 4-Difluoronitrobenzene reduction method: Add iron powder and ammonium chloride aqueous solution into the reduction kettle. After heating to reflux, add 2, 4-difluoronitrobenzene dropwise, and reflux for 2h after adding, and the reaction is complete. After steam distillation, the distillate is separated and dried with calcium chloride, qualified products can be obtained with a yield of 87%. 2. It is obtained from 1, 2, 4-trichlorobenzene through nitration, fluorination and reduction and dechlorination; or from m-phenylenediamine through diazotization, replacement, nitration and reduction.

View all

3.5 Usage: Substance is used in organic syntheses.

4. Safety and Handling

4.1 Fire Hazard: 2,4-Difluoroaniline is combustible. 2,4-Difluoroaniline Preparation Products And Raw materials Raw materials

4.2 Report: Reported in EPA TSCA Inventory.

4.3 Safety: Hazard Codes of 2,4-Difluoroaniline (CAS NO.367-25-9):?Xn,T,Xi
Risk Statements: 20/21/22-36/37/38?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 28-36/37/39-26?
S28: After contact with skin, wash immediately with plenty of soap-suds.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2941 6.1/PG 3
WGK Germany: 1
RTECS: BX3680000
F: 8-9-23
Hazard Note: Toxic
TSCA: T
HazardClass: 6.1
PackingGroup: III
HS Code 29214210
Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x and F^?.

View all

4.4 Toxicity: ORL-RAT LD50 820 mg kg-1, SKN-RAT LD50 672 mg kg-1

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Acute toxicity - Dermal, Category 3

Acute toxicity - Inhalation, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H311 Toxic in contact with skin H331 Toxic if inhaled
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/\u2026if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/\u2026if you feel unwell. P321 Specific treatment (see ... on this label). P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P311 Call a POISON CENTER/doctor/\u2026
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. NMR Spectrum

13C NMR : in CDCl3

1H NMR : 400 MHz in CDCl3

Mass

Mass spectrum (electron ionization)

7. Synthesis Route

367-25-9Total: 14 Synthesis Route

89-69-0 85 Suppliers

367-25-9 281 Suppliers

88-73-3

367-25-9 281 Suppliers

View all

8. Precursor and Product

precursor:

371-40-4

1481-68-1

108-70-3

74497-02-2

89-69-0

3296-04-6

1435-43-4

446-35-5

3847-58-3

product:

461-96-1

372-18-9

777-28-6

399-74-6

399-44-0

399-73-5

446-35-5

367-27-1

367-23-7

444-14-4

9. Computed Properties

Molecular Weight：129.11g/mol
Molecular Formula：C₆H₅F₂N
Compound Is Canonicalized：True
XLogP3-AA：129.03900549
Monoisotopic Mass：129.03900549
Complexity：97.1
Rotatable Bond Count：0
Hydrogen Bond Donor Count：1
Hydrogen Bond Acceptor Count：3
Topological Polar Surface Area：26
Heavy Atom Count：：9
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADcYBiAYAAAAAAAAAAAAAAAAAAAAAAAAAwAAAAAAAAAAABAAAAHQAQAAAACAiBEAgwwIBAAACAACRCQACCAAAgAgAIiAAAZIgIICKAkZGAIABgkAAIyAcQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10.Other Information

Usage: 2,4-Difluoroaniline is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Storage Conditions: 1.2, 4-Difluoronitrobenzene reduction method: Add iron powder and ammonium chloride aqueous solution into the reduction kettle. After heating to reflux, add 2, 4-difluoronitrobenzene dropwise, and reflux for 2h after adding, and the reaction is complete. After steam distillation, the distillate is separated and dried with calcium chloride, qualified products can be obtained with a yield of 87%. 2. It is obtained from 1, 2, 4-trichlorobenzene through nitration, fluorination and reduction and dechlorination; or from m-phenylenediamine through diazotization, replacement, nitration and reduction.

View all

Reactive Group: Aryl Halides

Reactivity Profile: Anilines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

View all

Fire Hazards: This compound is combustible. (NTP, 1992)

Nonfire Spill Response: SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should keep this material in a tightly closed container under an inert atmosphere, and store it at refrigerated temperatures. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)

View all

Personal Protective Equipment: RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

View all

Mesh Entry Terms: 2,4-difluoroaniline

Manufacturing Info: Benzenamine, 2,4-difluoro-: ACTIVE

11. Toltal 254 Suppliers View more

Wuhan Fortuna Chemical Co., Ltd.

^1YR

Tel: Update Time:2024/08/08

inquire

2,4-Difluoroaniline Low price high purity

Weifang Xingbei International Trade Co., Ltd

^1YR

Tel: Update Time:2024/11/15

inquire

2,4-Difluoroaniline 367-25-9 high purity low price hot sell in stock

Hubei Jiutian Bio-medical Technology Co., Ltd

^1YR

Tel: Update Time:2024/09/17

inquire

Hebei Yanxi Chemical Co.,Ltd

^1YR

Tel: Update Time:2024/11/14

inquire

High quality 2,4-Difluoroaniline CAS 367-25-9 in stock

Tianjin Furun Tongda International Trade Co., LTD

^1YR

Tel: Update Time:2024/11/15

inquire

12. Related Questions

: What is 2,4-Difluoroaniline and its Applications?2,4-Difluoroaniline, also known as 2,4-Difluoroaniline, is a pale yellow liquid at room temperature and pressure, with a slight amine odor. It is a fluorinated aniline compound with significant alkali..

13. Realated Product Infomation