Encyclopedia / Pharmaceutical Intermediates / Organic Intermediate / Organic Intermediates

3-Hydroxypicolinic acid

CAS：874-24-8
MW:139.1088
MF：C6H5NO3

Email Tweet Share

Names and ldentifier
Properties
Use and Manufacturing
Msds
NMR Spectrum
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: 3-Hydroxypicolinic acid

1.2 Synonyms: 2-Carboxy-3-hydroxypyridine; 2-PYRIDINECARBOXYLIC ACID, 3-HYDROXY-; 3-HPA; 3-Hydroxy-2-carboxypyridine; 3-Hydroxy-2-pyridine carboxylic acid; 3-Hydroxy-2-Pyridinecarboxylic; 3-HYDROXY-2-PYRIDINECARBOXYLIC ACID; 3-hydroxy-picolinic acid; 3-hydroxy-pyridine-2-carboxylic acid; 3-HYDROXYPYRIDINE-2-CARBOXYLIC ACID; EINECS 212-859-0; hydroxypicolinic acid; MFCD00006294; RARECHEM AL BO 0972; TIMTEC-BB SBB006727;

View all

1.3 CAS No.: 874-24-8

1.4 CID: 13401

1.5 EINECS: 212-859-0

1.6 Molecular Formula: C6H5NO3

1.7 Inchi: InChI=1S/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10)

1.8 InChkey: BRARRAHGNDUELT-UHFFFAOYSA-N

1.9 Canonical Smiles: C1=CC(=C(N=C1)C(=O)O)O

1.10 Isomers Smiles: C1=CC(=C(N=C1)C(=O)O)O

2. Properties

2.1 Solubility: Soluble in water (0.25g in 10ml).

2.2 Appearance: White to almost white Fine Powder

2.3 Storage: Ambient temperatures.

2.4 Chemical Properties: Light yellow Needles

2.5 Color/Form: White to almost white

2.6 pKa: 1.14±0.50(Predicted)

2.7 Water Solubility: soluble in water (0.25g in 10ml).

2.8 Stability: Stable at room temperature in closed containers under normal storage and handling conditions.

2.9 StorageTemp: Keep in dark place,Sealed in dry,Room Temperature

3. Use and Manufacturing

3.1 Definition: ChEBI: A monohydroxypyridine that is picolinic acid in which the hydrogen at position 3 is replaced by a hydroxy group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of oligonucleotides. 3-Hydroxypicolinic acidSupplier

View all

3.2 Description

3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.

Solid

3-hydroxypicolinic acid is a monohydroxypyridine that is picolinic acid in which the hydrogen at position 3 is replaced by a hydroxy group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of oligonucleotides. It has a role as a MALDI matrix material. It is a monohydroxypyridine and a monocarboxylic acid.

View all

4. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

5. NMR Spectrum

IR : KBr disc

IR : nujol mull

Mass

Mass spectrum (electron ionization)

6. Synthesis Route

874-24-8Total: 8 Synthesis Route

98-98-6 377 Suppliers

874-24-8 116 Suppliers

1121-25-1 173 Suppliers

874-24-8 116 Suppliers

View all

7. Precursor and Product

precursor:

98-98-6

1121-60-4

27507-15-9

1462-86-8

76045-30-2

98140-94-4

1121-25-1

1849-55-4

product:

272-62-8

109-00-2

14764-90-0

59718-84-2

24059-83-4

73406-50-5

62733-99-7

52605-89-7

13210-29-2

933-90-4

8. Computed Properties

Molecular Weight：139.1088g/mol
Molecular Formula：C₆H₅NO₃
Compound Is Canonicalized：True
XLogP3-AA：139.026943022
Monoisotopic Mass：139.026943022
Complexity：137
Rotatable Bond Count：1
Hydrogen Bond Donor Count：2
Hydrogen Bond Acceptor Count：4
Topological Polar Surface Area：70.4
Heavy Atom Count：：10
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADcYBiMAAAAAAAAAAAAAAAAAAAAAAAAAAsAAAAAAAAAAABgAAAHgAACAAACAzBlgQ8jpIIEgCoATT3TASCgCA3YiAI2CG/bNgKJ/bSlbOEcUhl4BHY2Qe4SAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

9.Other Information

Usage: 3-Hydroxypyridine-2-carboxylic acid is used as a matrix for nucleotides in MALDI mass spectrometry analyses.

BRN: 118954

Chemical Properties: Light yellow Needles

Uses: 3-Hydroxypicolinic acid (3-HPA) is a matrix material used in matrix-assisted laser desorption/ionization (MALDI) based mass spectroscopy (MS) for the analysis of large biomolecules and quantification of oligonucleotides.

Mesh Entry Terms: 3-hydroxy-2-pyridinecarboxylic acid

10. Toltal 111 Suppliers View more

High quality 3-Hydroxypicolinic acid CAS 874-24-8 with factory price

Wuhan Fortuna Chemical Co., Ltd.

^1YR

Tel: Update Time:2024/08/08

inquire

Wuhan Circle Star Chem-medical Technology Co.,Ltd

^1YR

Tel: Update Time:2024/11/15

inquire

Dayang Chem (Hangzhou) Co., Ltd.

^1YR

Tel: Update Time:2024/06/17

inquire

Hangzhou Tianye chemicals Co., Ltd

^1YR

Tel: Update Time:2024/10/22

inquire

Finetech Industry limited.

Tel: Update Time:2018/11/21

inquire

11. Related Questions

: What are the characteristics and applications of 3-Hydroxypicolinic acid?Introduction 3-Hydroxypicolinic acid, with the chemical formula C6H5NO3, is a white to off-white crystalline powder. It contains a pyridine ring in its molecular structure, and the nitrogen atom on th..; How can 3-Hydroxypicolinic Acid be synthesized? 3-hydroxyl group -2- Pyrimidine, as an important chemical, is widely used in many areas. This article will introduce its specific application in order to present readers' extensive application prospe..; Can you provide a concise synthesis method for 3-Hydroxypicolinic Acid? This article will explore the method of synthesizing 3- hydroxyl group -2- pyridin acid, so that readers will be able to better understand the preparation process of the compound. Background: Pyridin..

12. Realated Product Infomation