The 3-Nitrobenzaldehyde , with the CAS register number 99-61-6, has other names as 3-nitro-benzaldehyd;3 nitrobenzaldehyle;5-nitrobenzaldehyde;benzaldehyde, m-nitro-;benzaldehyde,3-nitro-;m-nitro-benzaldehyd;nitrobenzaldehyde-3;m-nitrobenzaldehyde .
The physical properties of this chemical are as the following：(1)#H bond acceptors:? 4 ; (2)#Freely Rotating Bonds:? 2? ; (3)Polar Surface Area:? 62.89; (4)Index of Refraction:? 1.617? ; (5)Molar Refractivity:? 39.55 cm3? ; (6)Molar Volume:? 112.9 cm3? ; (7)Polarizability:? 15.67× 10-24 cm3? ; (8)Surface Tension:? 55.1 dyne/cm? ; (9)Density:? 1.338 g/cm3? ; (10)Flash Point:? 128.6 °C? ; (11)Enthalpy of Vaporization:? 50.24 kJ/mol? ; (12)Boiling Point:? 264.5 °C at 760 mmHg? ; (13)Vapour Pressure:? 0.00966 mmHg at 25°C .
It is a kind of yellow crystalline solid and it is acicular while separate out of water. Being sensitive to air, it is soluble in mellow wine, ether, chloroform, and acetone while insoluble in water. As for its usage, it is widely used in many fields. First, it could be as the intermediate of organic synthesis, such as pharmaceutics, dying, and surfactant. Second, it could be used to composing the medicines in the pharmaceutic industry, such as iopanoic acid, Nimodipine, nicardipine, nitrendipine, and so on. As for its products category, they are various, including aromatic aldehydes & derivative;benzaldehyde;nicardipine;aldehydes;c7;carbonyl compounds.
Being an irritant chemical to eyes, respiratory system and skin, it may cause inflammation to the skin or other mucous membranes and it will be very harmful if swallowed. Then it is toxic to aquatic organisms and it may cause long-term adverse effects in the aquatic environment. So while dealing with it, we need to very cautious. Wear suitable protective clothing and eye/face protection and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And avoid contacting with skin and eyes. Besides, avoid releasing to the environment and then refer to special instructions/safety data sheet. What's more, do not empty into drains. If you need more safety information, you could refer to the WGK Germany? 3.
What's more, there is a simple way to produce the chemical in the lab. Prepare the raw material of benzaldehyde and then have the process of nitration under the existence of vitriol with nitrate of potash, sodium nitrate or hydrogen nitrate, then you could get the 3-Nitrobenzaldehyde, with the productivity of 80%、60% and 75%.
Its preparation products are including 3-Hydroxybenzaldehyde, 3-Chlorobenzaldehyde, Iopanoic acid, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, Nicardipine, 3-(3-Nitrophenyl)propionic acid, Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylate , etc. Besides, its raw materials are including Etanol, Ethyl acetate, Sulfuric acid, Dichloromethane, PETROLEUM ETHER, Nitric acid.
Below are the toxicity information of this chemcial：
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD |
intraperitoneal |
> 500mg/kg (500mg/kg) |
? |
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 144, 1954. |
| mouse |
LD50 |
intravenous |
180mg/kg (180mg/kg) |
? |
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02435, |
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