Encyclopedia / Pharmaceutical Intermediates / Organic Intermediate / Biochemicals and biotech products

GLYCYL-L-PROLINE

CAS：704-15-4
MW:172.184
MF：C7H12N2O3

N-Glycylproline was found to exhibit anti-ischemic effects on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia. View more+

Email Tweet Share

Names and ldentifier
Properties
Use and Manufacturing
Msds
NMR Spectrum
Other Information
Computational chemical data
Realated Product Infomation

1. Names and Identifiers

1.1 Name: GLYCYL-L-PROLINE

1.2 Synonyms: (S)-1-(2-Aminoacetyl)pyrrolidine-2-carboxylic acid; 1-(Aminoacetyl)proline; 1: PN: JP2018145111 PAGE: 3 claimed sequence; 1: PN: WO2017060857 PAGE: 93 claimed sequence; 11: PN: CN101988058 SEQID: 11 claimed sequence; 12: PN: WO2014063098 TABLE: 5 claimed sequence; 132: PN: US20130123467 SEQID: 158 claimed protein; 15: PN: WO2015153838 PAGE: 89 claimed sequence; 152: PN: EP2161028 PAGE: 10 claimed protein; 19: PN: WO2020009548 SEQID: 19 claimed protein; 1-Glycylproline; 2: PN: TWI417385 SEQID: 11 claimed sequence; 2: PN: WO2011150133 PAGE: 63 claimed sequence; 3: PN: WO2020023418 PAGE: 66 claimed sequence; 4: PN: WO2016023974 PAGE: 31 claimed sequence; 5: PN: WO2021055880 SEQID: 5 claimed protein; 7: PN: WO03052099 PAGE: 83 claimed protein; 81: PN: WO2011146121 PAGE: 115 claimed sequence; GLYCYL-L-PROLINE; GLY-PRO; GP (peptide); H-GLY-PRO-OH; L-Proline, 1-glycyl-; L-Proline, glycyl-; N-Glycyl-L-proline; N-Glycylproline; NSC 97929; Proline, 1-glycyl-, L-;

View all

1.3 CAS No.: 704-15-4

1.4 CID: 3013625

1.5 EINECS: 211-880-2

1.6 Molecular Formula: C7H12N2O3

1.7 Inchi: InChI=1S/C7H12N2O3/c8-4-6(10)9-3-1-2-5(9)7(11)12/h5H,1-4,8H2,(H,11,12)/t5-/m0/s1

1.8 InChkey: KZNQNBZMBZJQJO-YFKPBYRVSA-N

1.9 Canonical Smiles: C1CC(N(C1)C(=O)CN)C(=O)O

1.10 Isomers Smiles: C1C[C@H](N(C1)C(=O)CN)C(=O)O

2. Properties

2.1 Solubility: 易溶 (260 g/L) (25 oC),

2.2 Appearance: Solid

2.3 Chemical Properties: Crystalline

2.4 Color/Form: White to Yellow Solid

2.5 pKa: 3.18±0.20(Predicted)

2.6 Water Solubility: H2O: very faint turbidity

2.7 StorageTemp: −20°C

3. Use and Manufacturing

3.1 Definition: ChEBI: A dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group.

3.2 Description

H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.

Solid

Gly-Pro is a dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group. It has a role as a metabolite. It derives from a glycine and a L-proline. It is a tautomer of a Gly-Pro zwitterion.

View all

3.3 GHS Classification: Signal: Warning
GHS Hazard Statements
Aggregated GHS information provided by 24 companies from 2 notifications to the ECHA C&L Inventory.

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P264, P280, P305+P351+P338, P33, and P313

View all

3.4 Purification Methods: Crystallise glycyl-L-proline from water at 50-60o by addition of EtOH. [Saidel J Am Chem Soc 77 3893 1955, Bergmann et al. Z Physiol Chem 212 79 1932, Beilstein 22 IV 49.] GLYCYL-L-PROLINESupplier

3.5 Usage: N-Glycylproline was found to exhibit anti-ischemic effects on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia.

4. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Eye irritation, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H319 Causes serious eye irritation
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention.
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

View all

5. NMR Spectrum

13C NMR : in D2O

IR : KBr disc

Mass

Mass spectrum (electron ionization)

6. Synthesis Route

704-15-4Total: 17 Synthesis Route

147-85-3 620 Suppliers

704-15-4 24 Suppliers

837-83-2 15 Suppliers

56-41-7 624 Suppliers

704-15-4 24 Suppliers

View all

7. Precursor and Product

precursor:

147-85-3

1160-54-9

60189-43-7

72122-62-4

2646-61-9

3705-27-9

33256-35-8

23500-10-9

95688-74-7

837-83-2

product:

147-85-3

56-40-6

14296-92-5

8. Computed Properties

Molecular Weight：172.184g/mol
Molecular Formula：C₇H₁₂N₂O₃
Compound Is Canonicalized：True
XLogP3-AA：172.08479225
Monoisotopic Mass：172.08479225
Complexity：205
Rotatable Bond Count：2
Hydrogen Bond Donor Count：2
Hydrogen Bond Acceptor Count：4
Topological Polar Surface Area：83.6
Heavy Atom Count：：12
Defined Atom Stereocenter Count：1
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADccBjMAAAAAAAAAAAAAAAAAAAAWAAAAAAAAAAAAAAAAAAAAAAHgAQCAAACCjBgAQACANAAgAIAAGQGAAAAAAAAAAAAIGIAAACQBIAgCAUQAAEBgCQAACYEQIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==