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L-Alanine

CAS：56-41-7
MW:89.09318
MF：C3H7NO2

Alanine (also called 2-aminopropanoic acid, α-aminopropanoic acid) is an amino acid that helps the body convert the simple glucose into energy and eliminate excess toxins from the liver. Amino acids are the building blocks of important proteins and are key to building strong and healthy muscles. Alanine belongs to non-essential amino acids, which can be synthesized by the body. However, all amino acids may become essential if the body is unable to produce them. People with low-protein diets or eating disorders, liver disease, diabetes, or genetic conditions that cause Urea Cycle Disorders (UCDs) may need to take alanine supplements to avoid a deficiency. Alanine has been shown to help protect cells from being damaged during intense aerobic activity when the body cannibalizes muscle protein to produce energy. Alanine is used to support prostate health and is important for the regulation of insulin.L-alanine is the L-enantiomer of alanine. L-alanine is utilized in clinical nutrition as a component for parenteral and enteral nutrition. L-alanine plays a key role in transferring nitrogen from tissue sites to the liver. L-Alanine is widely used as nutrition supplements, as sweetener and flavor enhancer in the food industry, as flavor enhancer and preservative in the beverage industry, as intermediate for medicine manufacturing in pharmaceutical, as nutritional supplement and sour corrective agent in agriculture/animal feed, and as intermediate in manufacturing of various organic chemicals. View more+

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Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
NMR Spectrum
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: L-Alanine

1.2 Synonyms: (2S)-2-Aminopropanoic acid; (2S)-2-Azaniumylpropanoate; (S)-(+)-Alanine; (S)-2-Aminopropanoic acid; (S)-Alanine; 2-Amino-Propionic Acid; 8: PN: WO2021055880 SEQID: 9 claimed protein; Ala; Alanin; Alanine, L-; EINECS 200-273-8; Fmoc-L-Ala-OH; H-ALA-OH; H-Ala-OH~L-2-Aminopropionic acid; H-L-ALA-OH; L-(+)-Alanine; L-2-Aminopropanoic acid; L-2-Aminopropionic acid; Lactamine; L-ALA; L-alamine; L-alanine-12C3; L-ARANINE; L-α-Alanine; L-α-Aminopropionic acid; MFCD00064410; NSC 206315; Propanoic acid, 2-amino-, (S)-; Ritalanine;

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1.3 CAS No.: 56-41-7

1.4 CID: 5950

1.5 EINECS: 200-273-8

1.6 Molecular Formula: C3H7NO2

1.7 Inchi: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

1.8 InChkey: QNAYBMKLOCPYGJ-REOHCLBHSA-N

1.9 Canonical Smiles: CC(C(=O)O)N

1.10 Isomers Smiles: C[C@@H](C(=O)O)N

2. Properties

2.1 Solubility: H2O: 100?mg/mL

2.2 Appearance: White crystalline powder

2.3 Storage: Ambient temperatures.

2.4 Chemical Properties: A white, odorless powder having a sweet taste

2.5 Color/Form: Orthorhombic crystals from water
White crystalline powder

2.6 Odor: Odorless

2.7 PH: 5.5-6.5 (100g/l, H2O, 20℃)

2.8 pKa: 2.34(at 25℃)

2.9 Water Solubility: 166.5 g/L (25 oC)

2.10 Spectral Properties: Specific optical rotation= +2.42 deg for D-sodium line at 25 deg C (c = 10 in H2O); +13.7 deg for D sodium line at 25 deg C (c = 2.063 in 6N HCl)
SPECIFIC OPTICAL ROTATION: +2.8 DEG @ 25 DEG C/D (WATER, CONCN= 6%); SPECIFIC OPTICAL ROTATION: +9.55 DEG @ 25 DEG C/D (HYDROCHLORIC ACID)
MASS: 30598 (NIST/EPA/MSDC Mass Spectral Database, 1990 Version)
IR: 164 (Sadtler Research Laboratories IR grating collection)
UV: 2-10 (Phillip et al., Organic Electronic Spectral Data, John Wiley and Sons, New York)
Raman: 425 (Sadtler Research Laboratories spectral collection)
H1 NMR: 7553 (Sadtler Research Laboratories spectral collection)
C13 NMR: 36 (Johnson and Jankowski, Carbon-13 NMR Spectra, John Wiley and Sons, New York)

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2.11 Stability: Stable. Incompatible with strong oxidizing agents.

2.12 StorageTemp: Store at RT.

3. Use and Manufacturing

3.1 Definition: ChEBI: The L-enantiomer of alanine.

3.2 Description: L-Alanine (CAS 56-41-7) is a non-essential amino acid that plays a crucial role in protein synthesis and metabolism. It is an alpha-amino acid with the chemical formula C3H7NO2. L-Alanine is a white crystalline powder that is highly soluble in water. It has a molecular weight of 89.09 g/mol and a melting point of 314-316°C. This compound is odorless and has a slightly sweet taste.

Applicable Fields
L-Alanine has various applications in different fields:

Pharmaceutical Industry: L-Alanine is used as a pharmaceutical intermediate in the production of drugs and pharmaceuticals. It is also used as a nutritional supplement in the form of dietary supplements and sports nutrition products.

Food Industry: L-Alanine is used as a food additive in the production of various food products. It is commonly used as a flavor enhancer, stabilizer, and pH regulator. L-Alanine is also used in the fermentation process of certain food products.

Cosmetics Industry: L-Alanine is used in the formulation of cosmetics and personal care products. It is known for its moisturizing and skin conditioning properties. L-Alanine is often found in skincare products, hair care products, and body lotions.

Storage Conditions
L-Alanine should be stored in a cool and dry place, away from direct sunlight. It should be kept in a tightly sealed container to prevent moisture absorption. Proper storage conditions help maintain the stability and quality of the chemical.

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3.3 Purification Methods: Crystallise alanine from H2O or aqueous EtOH, i.e. crystallise it from 25% EtOH in water, or recrystallise it from 62.5% EtOH, wash it with EtOH and dry it to constant weight in vacuo over P2O5. [Gutter & Kegeles J Am Chem Soc 75 3893 1953, Walsh J Biol Chem 264 2394 1989.] 2,2'-Iminodipropionic acid is a likely impurity. [Beilstein 4 IV 2480. 2481.] L-Alanine Preparation Products And Raw materials Raw materials

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3.4 Usage: Alanine is an amino acid that can act as a skin-conditioning agent. It is usually used in combination with other amino acids.

4. Safety and Handling

4.1 Exposure Standards and Regulations: L-Alanine is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient.

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4.2 Octanol/Water Partition Coefficient: log Kow = -2.85

4.3 DisposalMethods: SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

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4.4 Safety Profile: Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

4.5 Formulations/Preparations: GRADES: REAGENT; TECHNICAL.
Reagent grade; USP and FCC grades

4.6 Report: Reported in EPA TSCA Inventory.

4.7 Safety: Hazard Codes of L-Alanine (CAS NO.56-41-7):?Xi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26?
S24/25:Avoid contact with skin and eyes.?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: AY2990000
F: 10
HazardClass: IRRITANT
HS Code: 29224995

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4.8 Specification: ? L-Alanine ,?its cas register number is 56-41-7. It also can be called? (S)-2-Aminopropanoic acid ; (S)-2-Aminopropionsaeure ; (S)-Alanine ; (S)-alpha-Aminopropionsaeure ; 2-Aminopropanoic acid, L- ; Alanina ; Alanine ;
?Alaninum?; L-(+)-Alanine ; L-2-Aminopropanoic acid ; L-2-Aminopropionic acid ; L-2-Aminopropionsaeure ; L-S-Aminopropionic acid ; L-alpha-Aminopropionic acid ; Propanoic acid, 2-amino-, (S)- ; alpha-Aminopropionic acid .

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4.9 Toxicity

???

sce-hmn:lyms 50?mg/L

???

MUREAV ?? Mutation Research. 280 (1992),279.

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5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s)	No symbol.
Signal word	No signal word.
Hazard statement(s)	none
Precautionary statement(s)
Prevention	none
Response	none
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

13C NMR : in D2O (PH 1.20)

13C NMR : in D2O (PH 6.38)

13C NMR : in D2O (PH 9.39)

13C NMR : Predict

1H NMR : 400 MHz in D2O

1H NMR : Predict

Predict 1H proton NMR

IR : KBr disc

IR : nujol mull

Raman : 4880 A,200 M,powder

Mass spectrum (electron ionization)

UV/Visible spectrum

7. Synthesis Route

56-41-7Total: 185 Synthesis Route

56-89-3 538 Suppliers

56-41-7 624 Suppliers

57-60-3

56-41-7 624 Suppliers

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8. Precursor and Product

precursor:

302-72-7

57-60-3

113-24-6

56-89-3

72-19-5

50-99-7

56-87-1

97-69-8

312-85-6

product:

302-72-7

338-69-2

6003-05-0

57-60-3

56-45-1

75-04-7

328-42-7

407-23-8

156-57-0

79-33-4

9. Computed Properties

Molecular Weight：89.09318g/mol
Molecular Formula：C₃H₇NO₂
Compound Is Canonicalized：True
XLogP3-AA：89.047678466
Monoisotopic Mass：89.047678466
Complexity：61.8
Rotatable Bond Count：1
Hydrogen Bond Donor Count：2
Hydrogen Bond Acceptor Count：3
Topological Polar Surface Area：63.3
Heavy Atom Count：：6
Defined Atom Stereocenter Count：1
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADcYBCMAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHgAQCAAACCjBgAQCCABAAgAIAACQCAAAAAAAAAAAAIGAAAACAAAAAAAAQAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10.Other Information

Usage: L-Alanine plays a vital role in glucose-alanine cycle between tissue and liver. It is used for protein construction as well as involved in the metabolism of tryptophan and vitamin pyridoxine. It provides energy for muscles and central nervous system in order to strengthen the immune system. It helps in the metabolism of sugars and organic acids, and enhances the germination rates of Bacillus subtilis spores. It also displays a cholesterol-reducing effect in animals.

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Usage: It is a key player in the Glucose-Alanine cycle, which enables the removal of pyruvate and glutamate from muscle to the liver. The Glucose-Alanine cycle aides to conserve ATP in muscle for muscle contraction, while the energy burden of gluconeogenesis is imposed upon the liver.

11. Toltal 568 Suppliers View more

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12. Related Questions

: How Can Metabolic Engineering Enhance L-Alanine Production Efficiency?General Description L-Alanine is a crucial compound utilized in various industries such as clinical medicine, food production, and the development of innovative materials like MGDA and biodegradable p..; What is the role of β- L-Alanine in improving exercise performance? β- L-Alanine is a non-essential amino acid that is typically combined with histidine to produce carnosine, stored in our skeletal muscles. Carnosine can effectively reduce lactic acid accumulation i..; What is L-Alanine and how does it benefit our health?With the continuous development of modern science and technology, people's concern for health is increasing. L-Alanine, as an important nutrient, has attracted more and more attention. This article wi..; Why is L-Alanine widely used in various industries?L-Alanine, as an important chiral compound, is primarily used as a precursor and intermediate in the synthesis of pharmaceuticals. It is also commonly used as a flavor enhancer, improving the taste of..

13. Realated Product Infomation