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(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde

CAS：15186-48-8
MW:130.143
MF：C6H10O3

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde, with the chemical formula C7H12O3 and CAS registry number 15186-48-8, is a compound known for its applications in various chemical processes. This colorless liquid, also referred to as (R)-(+)-Dimethyl-1,3-dioxolane-4-carboxaldehyde, is characterized by its dioxolane and carboxaldehyde functional groups. It is commonly used as a chiral building block in organic synthesis, offering a versatile platform for the introduction of the (R)-(+)-dimethyl-1,3-dioxolane-4-carboxaldehyde moiety into different molecules.

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Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde

1.2 Synonyms: (+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde; (4R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-CARBALDEHYDE; (4R)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde; (R )-2,2-Dimethyl-[1,3]dioxolane-4-carbaldehyde; (R)-(+)-Glyceraldehyde acetonide; (R)-2,2-DIMETHYL-[1,3]DIOXOLANE-4-CARBALDEHYDE; (R)-2,3-ISOPROPYLIDENE GLYCERALDEHYDE; (R)-Glyceraldehyde Acetonid; (R)-glyceraldehyde acetonide; (R)-Isopropylideneglyceraldehyde; 1,3-Dioxolane-4-carboxaldehyde, 2,2-dimethyl-, (4R)-; 1,3-DIOXOLANE-4-CARBOXALDEHYDE, 2,2-DIMETHYL-, (R)-; 2,3-Di-O-isopropylidene-D-glyceraldehyde; 2,3-O-(R)-ISOPROPYLIDENE-L-GLYCERALDEHYDE; 2,3-O-ISOPROPYLIDENE-D-GLYCERALDEHYDE; D-(R)-GLYCERALDEHYDE ACETONIDE; D-Glyceraldehyde acetonide; MFCD00269682;

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1.3 CAS No.: 15186-48-8

1.4 CID: 259712

1.5 EINECS: 227-244-2

1.6 Molecular Formula: C6H10O3

1.7 Inchi: InChI=1S/C6H10O3/c1-6(2)8-4-5(3-7)9-6/h3,5H,4H2,1-2H3/t5-/m0/s1

1.8 InChkey: YSGPYVWACGYQDJ-YFKPBYRVSA-N

1.9 Canonical Smiles: CC1(OCC(O1)C=O)C

1.10 Isomers Smiles: CC1(OC[C@@H](O1)C=O)C

2. Properties

2.1 Solubility: Difficult to mix.

2.2 Appearance: Oily liquid

2.3 Storage: Keep Cold.

2.4 Chemical Properties: Colorless Transparent Liquid

2.5 Color/Form: Colorless to Pale Yellow

2.6 Water Solubility: Difficult to mix.

2.7 StorageTemp: -20°C

3. Use and Manufacturing

3.1 Usage: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde is a reactant involved in organic reactions including:• ;Henry condensation reactions1• ;Synthesis of highly functionalized chiral aziridines2• ;Olefination of aldehydes3• ;C-H oxidations4• ;Aldol-type condensations5• ;Synthesis of hydrophilic pyrazine dyes for use as exogenous fluorescent tracer agents6• ;Hosomi-Sakurai reactions7 (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehydeSupplier

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4. Safety and Handling

4.1 Safety: WGK Germany: 3

4.2 Specification: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde (CAS NO.15186-48-8) is also called as Acetone D-glyceraldehyde ; (R)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde ; R)-2,3-isopropylidene glyceraldehyde ; 1,3-Dioxolane-4-carboxaldehyde, 2,2-dimethyl-, (r)- ; 2,3-O-isopropylidene-d-glyceraldehyde ; 2,3-o-(R)-isopropylidene-l-glyceraldehyde ; (4R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde ; D-(r)-glyceraldehyde acetonide .

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5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity \u2013 single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/\u2026if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. Synthesis Route

15186-48-8Total: 24 Synthesis Route

1707-77-3 173 Suppliers

15186-48-8 159 Suppliers

3969-61-7 9 Suppliers

15186-48-8 159 Suppliers

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7. Precursor and Product

precursor:

4306-35-8

70223-09-5

3427-24-5

3969-61-7

1707-77-3

64870-23-1

22323-82-6

22323-78-0

53735-98-1

product:

85820-82-2

52373-72-5

90472-93-8

23788-74-1

453-17-8

51268-87-2

82954-65-2

22323-82-6

79060-23-4

18524-18-0

8. Computed Properties

Molecular Weight：130.143g/mol
Molecular Formula：C₆H₁₀O₃
Compound Is Canonicalized：True
Exact Mass：0
XLogP3-AA：130.062994177
Monoisotopic Mass：130.062994177
Complexity：120
Rotatable Bond Count：1
Hydrogen Bond Donor Count：0
Hydrogen Bond Acceptor Count：3
Topological Polar Surface Area：35.5
Heavy Atom Count：：9
Defined Atom Stereocenter Count：1
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADccBgMAAAAAAAAAAAAAAAAAAAASAAAAAAAAAAAAAAAAAAAAAAGgAAAAAACBSggAICCAAABAAIAAgQgAIAAAAAAAAAAAFAAAARAAQAAAQiAAAAIAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

9.Other Information

Chemical Properties: Colorless Transparent Liquid

Uses: Reactant involved in organic reactions including:? ;Henry condensation reactions1? ;Synthesis of highly functionalized chiral aziridines2? ;Olefination of aldehydes3? ;C-H oxidations4? ;Aldol-type condensations5? ;Synthesis of hydrophilic pyrazine dyes for use as exogenous fluorescent tracer agents6? ;Hosomi-Sakurai reactions7

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Usage: Reactant involved in organic reactions including, Henry condensation reactions, Synthesis of highly functionalized chiral aziridines, Olefination of aldehydes, C-H oxidations, Aldol-type condensations, Synthesis of hydrophilic pyrazine dyes for use as exogenous fluorescent tracer agents.

Uses: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde is a reactant involved in organic reactions including:? ;Henry condensation reactions1? ;Synthesis of highly functionalized chiral aziridines2? ;Olefination of aldehydes3? ;C-H oxidations4? ;Aldol-type condensations5? ;Synthesis of hydrophilic pyrazine dyes for use as exogenous fluorescent tracer agents6? ;Hosomi-Sakurai reactions7

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Uses: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde_x000D__x000D_Discontinued, Unstable (cas# 15186-48-8) is a compound useful in organic synthesis.

Uses

Reactant involved in organic reactions including:

Henry condensation reactions
Synthesis of highly functionalized chiral aziridines
Olefination of aldehydes
C-H oxidations
Aldol-type condensations
Synthesis of hydrophilic pyrazine dyes for use as exogenous fluorescent tracer agents
Hosomi-Sakurai reactions

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10. Toltal 145 Suppliers View more

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde CAS 15186-48-8

Wuhan Fortuna Chemical Co., Ltd.

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(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde

CANGZHOU ENKE PHARMA-TECH CO.,LTD

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Factory Supply 2,3-O-isopropylidene- D-glyceraldehyde

Amitychem Corporation

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Tel: Update Time:2023/06/28

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Dayang Chem (Hangzhou) Co., Ltd.

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Tel: Update Time:2024/06/17

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1,3-Dioxolane-4-carboxaldehyde,2,2-dimethyl-, (4R)-

Jinlan Pharm-Drugs Technology Co., Limited

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11. Related Questions

: What is the application of (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde?(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde, also known as (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde, is a colorless to pale yellow liquid at room temperature and pressure. It is a c..; How to Prepare (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde?Background and Overview[1] (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde, also known as R-glyceraldehyde propylene ketal, is an intermediate in the synthesis of gemcitabine. Gemcitabine hydrochl..

12. Realated Product Infomation