Bisphenol A

1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Serious eye damage, Category 1

Skin sensitization, Category 1

Specific target organ toxicity \u2013 single exposure, Category 3

Reproductive toxicity, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H318 Causes serious eye damage H317 May cause an allergic skin reaction H335 May cause respiratory irritation H360F
Precautionary statement(s)
Prevention	P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood.
Response	P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor/\u2026 P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/\u2026if you feel unwell. P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Seek medical attention if you feel unwell.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Dusts irritating to upper respiratory passages; may cause sneezing. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, foam, powder, carbon dioxide.

5.2 Specific hazards arising from the chemical

This chemical is combustible. This compound may form explosive dust clouds. Static electricity can cause its dust to explode.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Vacuum cleaning is preferable to sweeping to keep dust levels down. Use special HEPA vacuum; not a shop vacuum. Ventilate area of spill or leak after cleanup is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from acid anhydrides, acid chlorides, strong oxidants, strong bases and food and feedstuffs. Store in an area without drain or sewer access.Safe Storage: Separated from acid anhydrides, acid chlorides, strong oxidants, strong bases and food and feedstuffs. Store in an area without drain or sewer access.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

CombustibleDust explosion possible if in powder or granular form, mixed with air.4,4'-ISOPROPYLIDENEDIPHENOL is incompatible with strong oxidizers. It is also incompatible with strong bases, acid chlorides and acid anhydrides.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizers, strong bases, acid chlorides, and acid anhydrides.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid and irritating fumes.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat (male, F344) oral 4100 mg/kg
• Inhalation: no data available
• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Menidia menidia (Atlantic silverside); Conditions: saltwater, flow through, 22\u00b0C, salinity 20 ppt; Concentration: 12000 ug/L for 24 hr (95% confidence interval: 9800-16000 ug/L) /polycarbonate grade, 99.93% purity
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, static, 20\u00b0C; Concentration: 15500 ug/L for 24 hr (95% confidence interval: 14400-16700 ug/L); Effect: intoxication, immobilization /polycarbonate grade, 99.93% purity
• Toxicity to algae: EC50; Species: Selenastrum capricornutum (Algae); Concentration: 2.7-3.1 mg/L for 96hr; EC50 values are based on 50% inhibition of cell count (2.7 mg/L) and total cell volume (3.1 mg/L) compared to controls. /Conditions of bioassay not specified
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Bisphenol A, present at 3 mg/L, exhibited a half-life of 3 days when incubated using natural receiving waters from a bisphenol A plant discharge in Houston, TX; a half-life of 2.5 days was measured using Patricks Bayou water, obtained 200 yards downstream from the plant discharge, and a half-life of 4 days was measured using Houston Ship Channel water(1). Loss was attributed to biodegradation since 3 mg/L bisphenol A in a control sample (deionized water) underwent no observable change in concentration over the 8 day test period(1). Incubation of 105 mg/L bisphenol A in an acclimated activated sludge inocula from an industrial wastewater treatment plant resulted in 72% COD removal in 24 hours(2). Using the OECD biodegradation screening test with domestic sewage as seed, <1% degradation was observed in 28 days(1). Bisphenol A was not oxidized in either the Closed Bottle Test nor the Modified Sturm Test; these results indicate a possible lack of acclimation by a domestic sludge as the compound was degraded in biotreators of chemical plants where the compound was produced or used(1). Bisphenol A, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(3). Of 40 Japanese river microcosms and 3 activated sludge samples tested, only 6 could completely mineralize this compound, resulting in 2 common metabolites: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol and p-hydroxyphenacyl alcohol; 19 bacteria were isolated from these activated sludge and river water samples(4). Further testing with the pure cultures suggested that bisphenol A-degrading bacteria exist in aquatic environments but they are unable to completely degrade this compound, leading to accumulation of more recalcitrant metabolites(4). In 22-day aerobic river die-away tests using several river water samples in 24 microcosms, bisphenol A showed complete degradation in 19 microcosms (complete mineralization in two microcosms) and no degradation in 5 microcosms(5).

12.3 Bioaccumulative potential

BCF ranges of <20 to approximately 67.7 and 5.1 to 13.3 from starting concentrations of 15 and 150 mg/L, respectively, were measured for bisphenol A using carp (Cyprinus carpio) which were exposed over an 8-week period(1). The following experimentally-determined BCF values have also been reported(2): 38 in spotted halibut (Varaspar variegates), 73.4 in killfish (Oryzias latipes). According to a classification scheme(3), these BCF values suggest the potential for bioconcentration in aquatic organisms is low to moderate(SRC). The BCF in freshwater clams, Pisidium amninum, was 114, 128, 134, and 107 at and 1.8, 5.8, 8.4, and 11.6\u00b0C, respectively, suggesting the importance of temperature on the processes that control uptake and elimination by aquatic biota(4).

12.4 Mobility in soil

A mean Koc value of 796 for bisphenol A was measured in soil adsorption experiments using four different agricultural soils from North-Rhine Westphalia and Rhineland-Palatinate, Germany and a bisphenol A concentration range of 0.04 to 5.00 mg/L; Koc values ranged from 636-931(1). Leaching studies in turf grass fields having loamy sand and sandy loam soils determined respective Koc values of 1751 and 3886(3); bisphenol A did not leach below a 30 cm soil layer(3). Batch experiments using soil samples from South Australia found Koc values ranging from 251 to 1507 (mean of 962)(4). Batch experiments using two acid sandy soils determined bisphenol A Koc values ranging from 335 to 703 (average of 375)(5). According to a classification scheme(6), a Koc range of 115 to 3886 suggests that Bisphenol A may have high to slight mobility in soil. Most of the measured Koc values suggest that bisphenol A may have moderate to low mobility in soil(SRC). The pKa of bisphenol A is 9.6(7), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(8). The partial dissociation of Bisphenol A in environmental media may be one reason for the wide range of observed soil adsorptions(SRC). An average bisphenol A Koc of 115 was determined in sorption studies using sediments from five locations on the Xiangjiang River in China(2).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.