Encyclopedia / Amine / Organic Intermediate / Other Inorganic Salts

Ammonium acetate

CAS：631-61-8
MW:77.083
MF：C2H7NO2

A white crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Ammonium acetate is used in chemical analysis, in pharmaceuticals, in preserving foods, and for other uses. View more+

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Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
NMR Spectrum
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: Ammonium acetate

1.2 Synonyms: [NH4](+)[OAc](-); Acetic acid, ammonium salt; AcO(-)NH4(+); ammonia acetate; AMMONIUM ACETATE TS; Ammonium aletate; ammonium ethanoate; Ammoniumacetat; AmmoniumAcetateA.R.; AmmoniumAcetateAcs9; AmmoniumAcetateGr; EINECS 211-162-9; MFCD00013066; Mindererus's spirit; NH4OAc; nitrilo acetic acid;

1.3 CAS No.: 631-61-8

1.4 CID: 517165

1.5 EINECS: 211-162-9

1.6 Molecular Formula: C2H7NO2

1.7 Inchi: InChI=1S/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3

1.8 InChkey: USFZMSVCRYTOJT-UHFFFAOYSA-N

1.9 Canonical Smiles: CC(=O)[O-].[NH4+]

1.10 Isomers Smiles: CC(=O)[O-].[NH4+]

2. Properties

2.1 Solubility: 1480 g/L (20 oC)

2.2 AnalyticLaboratory Methods: NIOSH Method 205 Analyte: Ammonia;; Matrix: Air; Procedure: Colorimetric. This method has a sensitivity of 0.002 mg. The range of application of this method is 0.10 mg to 0.80 mg of ammonium; in a 10 liter air sample. /Ammonia;/

2.3 Appearance: Ammonium acetate appears as a white crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used in chemical analysis, in pharmaceuticals, in preserving foods, and for other uses.

2.4 Storage: Hygroscopic. Store under Nitrogen. Ambient temperatures.

2.5 Color/Form: CRYSTALS OR CRYSTALLINE MASSES
WHITE CRYSTALS

2.6 Odor: SLIGHT ACETOUS ODOR

2.7 PH: VERY CONCENTRATED SOLN IS SLIGHTLY ACID & 0.5 MOLAR AQ SOLN HAS PH 7.0.

2.8 Physical: AMMONIUM ACETATE; is a white crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used in chemical analysis, in pharmaceuticals, in preserving foods, and for other uses.

2.9 pKa: 4.6(Acetic Acid), 9.3(Ammonium Hydroxide)(at 25℃)

2.10 Water Solubility: 148 G/100 CC WATER AT 4 DEG C; 7.89 G/100 CC METHANOL AT 15 DEG C

2.11 Stability: DELIQUESCENT; TENDS TO LOSE AMMONIA.

2.12 StorageTemp: 2-8°C

3. Use and Manufacturing

3.1 Description: Ammonium acetate is a white, deliquescent crystalline solid with a slightly acetic odor. It is used as a reagent in analytical chemistry for determining lead and iron content，a chemical intermediate in manufacturing acetamide. It is also a diuretic in veterinary medicine, in other drugs, in textile dyeing, in meat preservative, in foam rubbers, in vinyl plastics, in stripping explosives, and in determining lead and iron content.

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3.2 General Description: A white crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Ammonium acetate is used in chemical analysis, in pharmaceuticals, in preserving foods, and for other uses.

3.3 GHS Classification: Signal: Warning
GHS Hazard Statements
Aggregated GHS information provided by 1002 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 936 of 1002 companies. For more detailed information, please visit ECHA C&L website

Of the 5 notification(s) provided by 66 of 1002 companies with hazard statement code(s):

H302 (25.76%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (42.42%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (40.91%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501

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3.4 Methods of Manufacturing: From acetic acid; and ammonia;.

3.5 Potential Exposure: Ammonium acetate is used as a chemicalreagent, to make drugs; foam rubber; vinyl plastics;explosives, and to preserve foods. An environmental threat.

3.6 Purification Methods: Crystallise it twice from anhydrous acetic acid, and dry under vacuum for 24hours at 100o [Proll & Sutcliff Trans Faraday Soc 57 1078 1961].

3.7 Shipping: UN3077 Environmentally hazardous substances,solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardousmaterial, Technical Name Required.

3.8 Usage: Ammonium acetate is used in the manufacture of acetamide and as a diuretic and diaphoretic in medical applications. The wool industry also uses this salt as a dye mordant.Buffer solution; determination of lead and iron; separating lead sulfate from other sulfates.

4. Safety and Handling

4.1 Fire Hazard: Special Hazards of Combustion Products: Irritating vapors of ammonia acetic acid, and nitrogen oxides may form in fires.

4.2 Other Preventative Measures: SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

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4.3 Safety Profile: Poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NO, and NH3

4.4 Formulations/Preparations: COMMERCIAL PRODUCT CONTAINS 95-97% SALT WITH ACETIC ACID & SOME WATER.
GRADES OR PURITY: REAGENT; CP; TECHNICAL, 97+%
The acid salt is a double compound of the neutral salt with acetic acid.
/Available as/ crystal; reagent, purified; 65% solution, purified grades
/Available as/ 8 mesh particle size, 99.9 & 99.999% purity grades

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4.5 Incompatibilities: Combustible solid. Incompatible withoxidizers (chlorates, nitrates, peroxides, permanganates,perchlorates, chlorine, bromine, fluorine, etc.); contact maycause fires or explosions. Keep away from alkaline materials,strong bases, strong acids, oxoacids, epoxides, sodiumhypochlorite, potassium chlorate, sodium nitrite. Ammonium acetate Preparation Products And Raw materials Preparation Products

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4.6 Protective Equipment and Clothing: INHALATION OF DUST IRRITATES NOSE & MOUTH. CONTACT WITH DUST CAUSES IRRITATION OF EYES & MILD IRRITATION OF SKIN.

4.7 Report: Reported in EPA TSCA Inventory.

4.8 Skin, Eye, and Respiratory Irritations: INHALATION OF DUST IRRITATES NOSE & MOUTH. CONTACT WITH DUST CAUSES IRRITATION OF EYES & MILD IRRITATION OF SKIN.

4.9 Safety: Safety Information about?Ammonium acetate (CAS NO.631-61-8):
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
RIDADR: UN 9079
WGK Germany: 3
RTECS: AF3675000
F: 3
HS Code: 29152900
Poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NO_x and NH₃.

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4.10 Sensitive: Hygroscopic

4.11 Specification: General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.

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4.12 Toxicity: LD i.v. in mice: 1.8 mg (NH4+)/20g (Welch)

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s)	No symbol.
Signal word	No signal word.
Hazard statement(s)	none
Precautionary statement(s)
Prevention	none
Response	none
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

ESR : X-RAY IRRAD., 77K

13C NMR : in D2O

13C NMR : Predict

1H NMR : parameter in D20

1H NMR : Predict

IR : KBr disc

IR : nujol mull

Raman : 4880 A,200 M,powder

Mass

Mass spectrum (electron ionization)

7. Synthesis Route

631-61-8Total: 24 Synthesis Route

64-19-7 137 Suppliers

631-61-8 353 Suppliers

60-35-5 240 Suppliers

631-61-8 353 Suppliers

64-19-7 137 Suppliers

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8. Precursor and Product

precursor:

7664-41-7

60-35-5

130642-14-7

109-60-4

7732-18-5

64-19-7

53106-52-8

product:

56-40-6

93-26-5

1149-24-2

7664-41-7

60-35-5

1120-90-7

598-54-9

626-60-8

62-55-5

64-19-7

9. Computed Properties

Molecular Weight：77.083g/mol
Molecular Formula：C₂H₇NO₂
Compound Is Canonicalized：True
XLogP3-AA：77.047678466
Monoisotopic Mass：77.047678466
Complexity：25.5
Rotatable Bond Count：0
Hydrogen Bond Donor Count：1
Hydrogen Bond Acceptor Count：2
Topological Polar Surface Area：41.1
Heavy Atom Count：：5
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：2
CACTVS Substructure Key Fingerprint：AAADcYBCMAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGgAQAAAAAACAgAACCAAAAAAIAACQCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10.Other Information

Usage: Ammonium acetate is widely utilized as a catalyst in the Knoevenagel condensation. It is the primary source of ammonia in the Borch reaction in organic synthesis. It is used with distilled water to make a protein precipitating reagent. It acts as a buffer for electrospray ionization (ESI) mass spectrometry of proteins and other molecules and as mobile phases for high performance liquid chromatography (HPLC). Sometimes, it is used as a biodegradable de-icing agent and an acidity regulator in food additives.

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Usage: Ammonium acetate is used for routine precipitation of nucleic acids, and is especially useful for reducing the coprecipitation of unwanted dNTPs and contaminating oligosaccharides. It is used as an important reagent for studying molecular biology, biological buffers, reagents and DNA and RNA purification. It is a popular buffer for mobile phases for HPLC with ESLD detection, for ESI mass spectrometry of proteins and other molecules, and has been used to replace cell buffers with non-volitile salts. Ammonium acetate is also used in protein studies and protein preparation. It can be used in the protein purification steps of dialysis to remove contaminants through diffusion and, when combined with distilled water, as a protein precipitating agent. In organic chemistry, ammonium acetate solution is useful as a catalyst in the Knoevenagel condensation and as a source of ammonia in the Borch reaction. Additionally, it is occasionally used commercially as a biodegradable de-icing agent and as an additive in food as an acidity regulator.

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Usage: Ammonium acetate is a reagent used in chromatographic analysis of various compounds such as oligos, proteins, and peptides. It is also employed with acetic acid to provide a buffer solution. Generally it behaves as a catalyst in many reactions like Knoevenagel, Borch. It is also employed as a nutrient additive.

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12. Related Questions

: What is the main usage of Ammonium acetate?Ammonium acetate, also known as ammonium ethanoate, is a white triangular crystal with a vinegar-like odor. Due to the similar hydrolysis degree of acetate and ammonium ions, the pH of the solution is..; What makes Ammonium Acetate a versatile compound for buffer solutions?Ammonium acetate is a unique salt formed by a weak acid and a weak base. When dissolved in water, it maintains a neutral pH of 7. This compound hydrolyses into ammonia and acetic acid, which dissociat..; Is Ammonium Acetate Toxic? What You Need to KnowWhen handling various chemicals in daily operations, it is important to take proper protective measures. This is because these substances can be harmful to our health. Accidental contact or ingestion ..; What are the physical and chemical properties of Ammonium acetate?Ammonium acetate, also known as ethanoic acid ammonium, is an organic compound and a white crystalline substance. It is primarily used as a preservative and chemical reagent in daily life. However, it..

13. Realated Product Infomation