Encyclopedia / Agrochemical Intermediates / Organic Intermediate / Pharmaceutical Intermediates

Fmoc-O-trityl-L-serine

CAS：111061-56-4
MW:569.657
MF：C37H31NO5

Fmoc-O-trityl-L-serine, with the chemical formula C51H45NO5 and CAS registry number 111061-56-4, is a compound known for its applications in peptide synthesis. This compound is a derivative of serine, an amino acid commonly found in proteins. Fmoc-O-trityl-L-serine is often used as a protecting group in peptide synthesis, providing stability to the amino acid during the synthesis process. It is characterized by the Fmoc (9-fluorenylmethoxycarbonyl) protecting group and the trityl (triphenylmethyl) protecting group. These groups can be selectively removed to expose the reactive amino group for further peptide chain elongation. Fmoc-O-trityl-L-serine is an important tool in the field of peptide chemistry, allowing for the efficient and controlled synthesis of complex peptides and proteins.

View more+

Email Tweet Share

Names and ldentifier
Properties
Use and Manufacturing
Msds
Other Information
Computational chemical data
Realated Product Infomation

1. Names and Identifiers

1.1 Name: Fmoc-O-trityl-L-serine

1.2 Synonyms: Fmoc-L-Ser(OTrt)-OH; FMOC-L-SER(TRT)-OH; FMOC-L-SER(TRT)-OH FMOC-O-TRITYL-L-SERINE FMOC-SERINE(TRT)-OH FMOC-SER(TRT)-OH n-(9-fluorenylMethoxycarbonyl)-o-trityl-l-serine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-TRITYL-L-SERINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TRITYL-L-SERINE N-ALPHA-FMOC-O; Fmoc-Ser(OTrt)-OH; FMoc-Ser(trt); FMOC-SER(TRT)-OH; L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(triphenylmethyl)-; L-Serine, N-formyl-O-(triphenylmethyl)-; MFCD00153364; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-trityl-L-serine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tritylserine; N-Fmoc-L-Ser-(Trt)-OH; N-Formyl-O-trityl-L-serine; Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(triphenylmethyl)-;

View all

1.3 CAS No.: 111061-56-4

1.4 CID: 11519790

1.5 EINECS: 1533716-785-6

1.6 Molecular Formula: C37H31NO5

1.7 Inchi: InChI=1S/C37H31NO5/c39-35(40)34(38-36(41)42-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-43-37(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,38,41)(H,39,40)/t34-/m0/s1

1.8 InChkey: UCARTONYOJORBQ-UMSFTDKQSA-N

1.9 Canonical Smiles: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC(C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

1.10 Isomers Smiles: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC[C@@H](C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

2. Properties

2.1 Appearance: white to light yellow crystal powder

2.2 Chemical Properties: white to light yellow crystal powde Fmoc-O-trityl-L-serineSupplier

2.3 pKa: 3.33±0.10(Predicted)

2.4 StorageTemp: 2-8°C

3. Use and Manufacturing

3.1 Description

Fmoc-O-trityl-L-serine, with the chemical formula C43H35NO4, has the CAS number 111061-56-4. It is a chemical compound used in organic synthesis. Fmoc-O-trityl-L-serine appears as a white to off-white solid with no distinct odor. Its basic structure consists of a serine molecule with a trityl protecting group attached to the oxygen atom of the serine side chain. This compound is sparingly soluble in water, but soluble in organic solvents such as methanol and dimethylformamide. Fmoc-O-trityl-L-serine is stable under normal conditions and poses no immediate safety hazards. However, as with any chemical, proper handling and storage precautions should be followed to ensure safety.

Applicable Fields

Organic Synthesis: Fmoc-O-trityl-L-serine is commonly used in organic synthesis as a building block for the preparation of peptides and other organic compounds. Its purpose in this field involves its ability to serve as a protected amino acid, allowing for selective modification and assembly of peptide chains. The mechanism of action in organic synthesis involves the removal of the Fmoc protecting group under specific reaction conditions, followed by further chemical transformations to achieve the desired product.

Storage

Conditions: Store in a cool and dry place, away from direct sunlight.

View all

4. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Precautionary statement(s)
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

2.3 Other hazards which do not result in classification

no data available

View all

5. Synthesis Route

111061-56-4Total: 1 Synthesis Route

28920-43-6 227 Suppliers

25840-83-9

111061-56-4 82 Suppliers

6. Precursor and Product

precursor:

28920-43-6

25840-83-9

product:

25840-83-9

16053-39-7

110797-35-8

7. Computed Properties

Molecular Weight：569.657g/mol
Molecular Formula：C₃₇H₃₁NO₅
Compound Is Canonicalized：True
Exact Mass：7.2
XLogP3-AA：569.22022309
Monoisotopic Mass：569.22022309
Complexity：837
Rotatable Bond Count：11
Hydrogen Bond Donor Count：2
Hydrogen Bond Acceptor Count：5
Topological Polar Surface Area：84.9
Heavy Atom Count：：43
Defined Atom Stereocenter Count：1
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADceB+OAAAAAAAAAAAAAAAAAAAAYAAAAAwYMGDAAAAAGABVAAAHgAQCAAADWzhmAYwCILABgCIAiDSGAACAAAgAAAIiIGICIkKJiaAMTiLcAAl9gEYqAeAwPAOgAAAAAAQAAAAAAAAACAAAQAACAAAAA==