Encyclopedia

Glyprothiazol

CAS：80-34-2
MW:298.379
MF：C11H14N4O2S2

Email Tweet Share

Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
Computational chemical data

1. Names and Identifiers

1.1 Name: Glyprothiazol

1.2 Synonyms: 2-Sulfanilamido-5-isopropylthiadiazole; 4-amino-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; 4-amino-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; 4-Amino-N-[5-(1-methylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide; Benzenesulfonamide, 4-amino-N-[5-(1-methylethyl)-1,3,4-thiadiazol-2-yl]-; Glyprothiazol; Glyprothiazole; Glyprothizol; IPTD; N1-(5-Isopropyl-1,3,4-thiadiazol-2-yl)sulfanilamide; PASIT; RP 2254; RP-2254; Sulfaisopropylthiadiazole; Sulfanilamide, N1-(5-isopropyl-1,3,4-thiadiazol-2-yl)-; VK 57; VK-57;

View all

1.3 CAS No.: 80-34-2

1.4 CID: 66458

1.5 Molecular Formula: C11H14N4O2S2

1.6 Inchi: InChI=1S/C11H14N4O2S2/c1-7(2)10-13-14-11(18-10)15-19(16,17)9-5-3-8(12)4-6-9/h3-7H,12H2,1-2H3,(H,14,15)

1.7 InChkey: OPIGMRDAPFQALU-UHFFFAOYSA-N

1.8 Canonical Smiles: CC(C)C1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N

1.9 Isomers Smiles: CC(C)C1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N

2. Properties

2.1 Solubility: 218.7mg/L(37 ºC)

2.2 Water Solubility: 218.7mg/L(37 oC)

3. Use and Manufacturing

3.1 Description: Glyprothiazol is a sulfonamide derivative with antihyperglycemic activity. Like sulfonylureas, glyprothiazol is able to lower blood glucose levels by increasing the release of insulin from pancreatic beta cells.

4. Safety and Handling

4.1 Toxicity: LD50 oral in rat: 3940mg/kg

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Precautionary statement(s)
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

2.3 Other hazards which do not result in classification

no data available

View all

6. Synthesis Route

80-34-2Total: 4 Synthesis Route

121-60-8 134 Suppliers

80-34-2 1 Suppliers

27115-74-8 13 Suppliers

80-34-2 1 Suppliers

View all

7. Precursor and Product

precursor:

121-60-8

107415-40-7

312756-34-6

27115-74-8

8. Computed Properties

Molecular Weight：298.379g/mol
Molecular Formula：C₁₁H₁₄N₄O₂S₂
Compound Is Canonicalized：True
XLogP3-AA：298.05581805
Monoisotopic Mass：298.05581805
Complexity：388
Rotatable Bond Count：4
Hydrogen Bond Donor Count：2
Hydrogen Bond Acceptor Count：7
Topological Polar Surface Area：135
Heavy Atom Count：：19
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADccBzsABgAAAAAAAAAAAAAAAAAWAAAAAwAAAAAAAAAAABwAAAHAQYQAAADQiBUgAz0YBAAAqmACRiYHDSAJJgAhEciBgwZIgIICKgkZGAIABwmAAIyAcQAAAAAAQAAAAAAAAACAAAAAAAAAAAAAAAAA==

1. Names and Identifiers

1.1 Name
1.2 Synonyms
1.3 CAS No.
1.4 Molecular Formula
1.5 Inchi
1.6 InChkey
1.7 Canonical Smiles
1.8 Isomers Smiles

2. Properties

2.1 Solubility
2.2 Water Solubility

3. Use and Manufacturing

3.1 Description

4. Safety and Handling

4.1 Toxicity

5. Msds

6. Synthesis Route

7. Precursor and Product

8. Computational chemical data

CAS Products Suppliers