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Hyaluronicacidsodiumsalt

CAS：9004-61-9
MW:403.316
MF：C14H22NNaO11

Hyaluronic acid sodium salt (CAS 9004-61-9) is a compound that is widely used in the field of medicine and cosmetics. It is a polysaccharide composed of repeating units of glucuronic acid and N-acetylglucosamine. This compound is known for its ability to retain moisture, making it a popular ingredient in skincare products. Hyaluronic acid sodium salt is also used in various medical applications, such as joint injections for the treatment of osteoarthritis and as a filler for cosmetic procedures. Its unique properties make it an important component in the development of biomaterials and drug delivery systems. Overall, hyaluronic acid sodium salt plays a crucial role in the fields of medicine and cosmetics, offering a range of applications due to its moisturizing and therapeutic properties.

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Names and ldentifier
Properties
Use and Manufacturing
Msds
Other Information
Related Questions

1. Names and Identifiers

1.1 Name: Hyaluronicacidsodiumsalt

1.2 Synonyms: (2S,3S,4R,5R)-6-{[(2R,3R,4R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-2-methoxyoxan-4-yl]oxy}-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid; [BETA-SODIUM-GLUCONATE-(1,3)-BETA-N-ACETYL-D-GLUCOSAMINE-1,4-]N; acid hyaluronic; COPOLY(BETA-GLUCURONIC ACID-[1->3]-BETA-N-ACETYLGLUCOSAMINE-[1->4] SODIUM SALT; Hyaluronic acid; HYALURONIC ACID HUMAN SODIUM SALT; HYALURONIC ACID NA-SALT; HYALURONIC ACID SODIUM; HYALURONIC ACID, SODIUM SALT, STREPTOCOCCUS SPECIES; Methyl 2-acetamido-2-deoxy-3-O-(4-O-methyl-α-D-glucopyranuronosyl)-β-D-glucopyranoside; sodiuM (2S,3S,4R,5R,6R)-3-((2S,3R,5S,6R)-3-acetaMido-5-hydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yloxy)-4,5,6-trihydroxytetrahydro-2H-pyran-2-carboxylate; β-D-Glucopyranoside, methyl 2-(acetylamino)-2-deoxy-3-O-(4-O-methyl-α-D-glucopyranuronosyl)-;

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1.3 CAS No.: 9004-61-9

1.5 EINECS: 232-678-0

1.6 Molecular Formula: C14H22NNaO11

1.7 Inchi: InChI=1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)/t7-,8-,9-,10-,11-,12-,13+,14?,15-,16-,17-,18-,19?,20+,21+,22?,25?,26+,27+,28-/m1/s1

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1.8 InChkey: KIUKXJAPPMFGSW-YXBJCWEESA-N

1.9 Canonical Smiles: CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)C)O)O

1.10 Isomers Smiles: CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](OC1O)CO)O)O[C@H]2[C@@H]([C@H]([C@@H](C(O2)C(=O)O)O[C@H]3[C@@H](C([C@@H]([C@H](O3)CO)O)O[C@@H]4[C@@H]([C@H](C([C@H](O4)C(=O)O)O)O)O)NC(=O)C)O)O

2. Properties

2.1 StorageTemp: ?20°C

3. Use and Manufacturing

3.1 Description

Hyaluronic acid sodium salt, with the chemical formula C14H20NNaO11, has the CAS number 9004-61-9. It is a polysaccharide belonging to the class of glycosaminoglycans. It appears as a white powder with no odor. Its basic structure consists of repeating units of D-glucuronic acid and N-acetyl-D-glucosamine linked together. This compound is highly soluble in water. Hyaluronic acid sodium salt is generally considered safe for use in cosmetics and medical applications. It is non-toxic and non-irritating to the skin. However, individuals with a known allergy to hyaluronic acid should avoid using products containing this compound. It is important to note that hyaluronic acid sodium salt is a natural component of the human body and is commonly found in the skin, joints, and eyes.

Applicable Fields

Cosmetics: Hyaluronic acid sodium salt is widely used in the cosmetics industry for its moisturizing and anti-aging properties. It is commonly found in skincare products such as serums, creams, and masks. The mechanism of action in cosmetics involves its ability to attract and retain moisture, resulting in hydrated and plump skin. Hyaluronic acid sodium salt also helps to improve the appearance of fine lines and wrinkles.

Medical: Hyaluronic acid sodium salt is used in various medical applications, including ophthalmology, orthopedics, and dermatology. In ophthalmology, it is used as a viscoelastic agent during eye surgeries and as a lubricant for dry eyes. In orthopedics, it is used as a joint lubricant and for the treatment of osteoarthritis. In dermatology, it is used for dermal fillers and wound healing. The mechanism of action in these medical fields involves its ability to provide lubrication, cushioning, and support to the tissues.

Storage

Conditions: Store in a cool and dry place.

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4. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s)	No symbol.
Signal word	No signal word.
Hazard statement(s)	none
Precautionary statement(s)
Prevention	none
Response	none
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

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5. Synthesis Route

9004-61-9Total: 1 Synthesis Route

9067-32-7 429 Suppliers

9004-61-9 571 Suppliers

6. Precursor and Product

precursor:

9067-32-7

product:

9067-32-7

7.Other Information

Forms and nomenclature: dietary supplements； face creams； serums； eye drops； injections

Hyaluronic Acid: Hyaluronic acid is a completely transparent, non-adhesive, water-soluble and grease-free acid mucopolysaccharide. Its molecular weight is between a few hundred thousand to millions, and it makes up the dermis layer of the skin. Its unique molecular structure and physicochemical properties has many important physiological functions inside the body, such as lubricating joints, adjusting vascular permeability, adjusting proteins, diffusing and transporting water electrolytes, and promoting wound healing. Hyaluronic acid has a unique water retention effect and has the best known natural moisturizing properties, making it the ideal natural moisturizer.
Hyaluronic acid is an essential drug in ophthalmic “sticky surgeries”. It is used in cataract surgery, in which its sodium salt remains in the anterior chamber to maintain depth in the anterior chamber and ensure a clear surgical view. It reduces the occurences of postoperative inflammation and complications, thus improving the vision-correcting effects of the surgery. It is also used in complicated retinol detachment surgery. Hyaluronic acid has a low molecular weight and is considered the ideal natural moisturizing agent, so it is used as an additive in high-end makeup and as a moisturizer in creams, gels, lotions, masks, and serums. It is also used medically as a moisturizer to improve moisture retention and lubrication, and it also expands capillaries and improves skin health. For example, hyaluronic acid with a low molecular weight can be used as a lubricant in surgeries (such as knee surgery), while those with high molecular weight can be used as surgical lubricant and as a substitute for vitreous in ophthalmic surgery.

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Benefits

Hyaluronic acid’s main functions include:

Has excellent affinity to water and can regroup water within tissue for better retention and lubrication.
Folds to form a three-dimensional network and produces physiological effects, including producing fluid resistance, maintaining water balance and bodily stability, influencing macromolecule solubility, structure, chemical balance and system osmotic pressure, preventing the spread of pathogens, and promote the condensation of collagen fiber secretory substances.
Forms polymers with inseparable proteins to maintain tissue shape and size and to ensure reversible tissue compression resistance.
Affects macrophages, adherent cells, lymph cells, and natural killer cells.
Serves as an important part of interstitial fluid and is mainly metabolized in the liver. Liver fiber activity increases HA synthesis; combined with reduced function during cirrhosis, blood HA levels may increase abnormally.

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Side effects: Studies show that hyaluronic acid with lower molecular weights penetrates deeper into the skin, which can cause inflammation.

Uses: hyaluronic acid is a glycosaminoglycan component. Hyaluronic acid occurs naturally in the dermis. It is thought to play a critical role in healthy skin by controlling the physical and biochemical characteristics of epidermal cells. It also regulates general skin activity, such as water content, elasticity, and the distribution of nutrients. Its water-absorption abilities and large molecular structure allow the epidermis to achieve greater suppleness, proper plasticity, and turgor. Hyaluronic acid is a natural moisturizer with excellent water-binding capabilities. In a solution of 2 percent hyaluronic acid and 98 percent water, the hyaluronic acid holds the water so tightly that it appears to create a gel. However, it is a true liquid in that it can be diluted and will exhibit a liquid’s normal viscous flow properties. When applied to the skin, hyaluronic acid forms a viscoelastic film in a manner similar to the way it holds water in the intercellular matrix of dermal connective tissues. This performance and behavior suggests that hyaluronic acid makes an ideal moisturizer base, allowing for the delivery of other agents to the skin. Manufacturers claim that the use of hyaluronic acid in cosmetics results in the need for much lower levels of lubricants and emollients in a formulation, thereby providing an essentially greaseless product. Furthermore, its ability to retain water gives immediate smoothness to rough skin surfaces and significantly improves skin appearance. For the benefits of hyaluronic acid to be realized in a cosmetic, the product needs to be applied on a regular basis as it is broken down in skin within 24 to 48 hours of application. note, this is not the case with hyaluronic acid injections as the technology used is different.

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Uses: Synovitis agent (veterinary).

Uses: Hyaluronic acid is a naturally derived, non - immunogenic, non - adhesive glycosaminoglycan that plays a prominent role in various wound - healing processes, as it as it is naturally angiogenic when degraded to small fragments. Hyaluronic acid promotes early inflammation which is critical for initiating wound healing, but then moderates later stages of the process, allowing matrix stabilization and reduction of long term inflammation. Hyaluronic acid is a main source for pharmaceutical, medical and cosmetic application.

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Definition: hyaluronic acid: A glycosaminoglycan(mucopolysaccharide) that ispart of the matrix of connective tissue.Hyaluronic acid binds cells togetherand helps to lubricate joints.It may play a role in the migration ofcells at wounds; this activity ceaseswhen hyaluronidase breaks downhyaluronic acid.

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Definition: ChEBI: A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates.

Brand name: Equron [Veterinary] (Fort Dodge Animal Health); Legend (Bayer Animal Health); Synacid [Veterinary] (Schering-Plough Animal Health).

Veterinary Drugs and Treatments: Hyaluronic acid is a natural complex sugar of the glycosaminoglycan family and is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine. Hyaluronic acid is indicated for use as a surgical aid in cataract extraction (intra-and extracapsular), IOL implantation, corneal transplant, glaucoma filtration and retinal attachment surgery. In surgical procedures in the anterior segment of the eye, instillation of hyaluronic acid serves to maintain a deep anterior chamber within corneal endothelium and other surrounding tissues. Furthermore, its viscoelasticity helps to push back the vitreous face and prevent formation of a postoperative flat chamber. In posterior segment surgery hyaluronic acid serves as a surgical aid to gently separate, maneuver and hold tissues. Hyaluronic acid creates a clear field of vision thereby facilitating intra- and post-operative inspection of the retina and photocoagulation.

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9. Related Questions

: What is Hyaluronic Acid Sodium Hyaluronate Salt and its Benefits? Introduction: HyaluronicAcidSodiumsalt is a kind of polysaccharide that naturally exists in the human body, which is widely distributed in connective tissues, epithelial tissues and nerve tissues. Be..; What are the Benefits of Hyaluronic Acid in Skincare and Haircare?Hyaluronic acid, a natural active ingredient classified as a polysaccharide, can be produced through the fermentation of specific bacteria. It is naturally present in the eyes, skin, and joints of the..; What are the Uses of Hyaluronic Acid?Biological function of Hyaluronic acid Hyaluronic acid (HA) is a natural substance found in the eyes, joints, and skin. It acts as a cushion and lubricant in joints and other tissues. It is used to tr..; Is Shandong Anhua Biopharmaceutical Co., Ltd. Leading the Way in Hyaluronic Acid Sodium Salt Production?Shandong Anhua Biopharmaceutical Co., Ltd. is dedicated to the production and research of Hyaluronic Acid Sodium Salt. As an advanced pharmaceutical company, the company possesses cutting-edge product..

1. Names and Identifiers

1.1 Name
1.2 Synonyms
1.3 CAS No.
1.4 EINECS(EC#)
1.5 Molecular Formula
1.6 Inchi
1.7 InChkey
1.8 Canonical Smiles
1.9 Isomers Smiles

2. Properties

2.1 StorageTemp

3. Use and Manufacturing

3.1 Description

4. Msds

5. Synthesis Route

6. Precursor and Product

7. Other Information

8. Toltal 516 Suppliers

9. Related Questions

CAS Products Suppliers