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Methylcarbamic acid phenyl ester structure

Methylcarbamic acid phenyl ester
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1. Names and Identifiers
1.1 Name
Methylcarbamic acid phenyl ester
1.2 Synonyms
Carbamic acid, methyl-, phenyl ester; Carbamic acid, N-methyl-, phenyl ester; CARBAMICACID,METHYL-,PHENYLESTER; DRC 3345; Methylcarbamic acid phenyl ester; N-Methylcarbamic acid phenyl ester; N-METHYLPHENYLCARBAMATE; NSC 128138; Phenmec; Phenyl methylcarbamate; Phenyl N-methylcarbamate; PHENYL-N-METHYL-CARBAMATE; S 101;
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1.3 CAS No.
1943-79-9
1.4 CID
16034
1.5 EINECS
815-597-0
1.6 Molecular Formula
C8H9NO2
1.7 Inchi
InChI=1S/C8H9NO2/c1-9-8(10)11-7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10)
1.8 InChkey
SCWKRWCUMCMVPW-UHFFFAOYSA-N
1.9 Canonical Smiles
CNC(=O)OC1=CC=CC=C1
1.10 Isomers Smiles
CNC(=O)OC1=CC=CC=C1
2. Properties
2.1 pKa
11.54±0.46(Predicted)
3. Use and Manufacturing
3.1 Methods of Manufacturing
FORMERLY BY THE REACTION OF METHYL ISOCYANATE WITH PHENOL OR BY THE REACTION OF PHENYL CHLOROFORMATE WITH METHYLAMINE
4. Safety and Handling
4.1 Octanol/Water Partition Coefficient
1.24
4.2 Safety

 Phenylmonomethylcarbamate (CAS NO.1943-79-9) is poisonous by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When Phenylmonomethylcarbamate (CAS NO.1943-79-9) is heated to decomposition, it emits toxic fumes of NOx. See also CARBAMATES and ESTERS.

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4.3 Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral > 100mg/kg (100mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 15, Pg. 287, 1967.
mouse LD50 intravenous > 50mg/kg (50mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 National Technical Information Service. Vol. PB158-508,
rat LD50 intraperitoneal 357mg/kg (357mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Bulletin of the World Health Organization. Vol. 44, Pg. 241, 1971.
rat LD50 intravenous 13600ug/kg (13.6mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Bulletin of the World Health Organization. Vol. 44, Pg. 241, 1971.
rat LD50 oral 540mg/kg (540mg/kg)   Bulletin of the World Health Organization. Vol. 44, Pg. 241, 1971.

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5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available
Precautionary statement(s)
Prevention

no data available

Response

no data available

Storage

no data available

Disposal

no data available

2.3 Other hazards which do not result in classification

no data available

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6. Synthesis Route
1943-79-9Total: 9 Synthesis Route
 
1885-14-9
1885-14-9 93 Suppliers
 
1943-79-9
1943-79-9 9 Suppliers
 
161001-98-5
161001-98-5
 
1943-79-9
1943-79-9 9 Suppliers
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7. Precursor and Product
precursor:
14128-35-9
14128-35-9
1885-14-9
1885-14-9
6642-30-4
6642-30-4
593-51-1
593-51-1
161001-98-5
161001-98-5
30379-59-0
30379-59-0
108-95-2
108-95-2
161001-97-4
161001-97-4
product:
92988-97-1
92988-97-1
75930-29-9
75930-29-9
652156-53-1
652156-53-1
62183-21-5
62183-21-5
8. Computed Properties
9.Other Information
Abiotic Degradation
PHOTODECOMPOSITION OF PHENMEC (PHENYL-N-METHYLCARBAMATE) RESULTS IN PHENOL, 2-HYDROXY-N-METHYL-BENZAMIDE, 4-HYDROXY-N-METHYL BENZAMIDE AND BENZENE. PHOTODECOMPOSITION PRECEEDS VIA ALPHA AND BETA CLEAVAGE.
Metabolism
PHENYL N-METHYLCARBAMATE IS METABOLIZED TO PHENYL N-HYDROXYMETHYLCARBAMATE IN MOUSE. HOOK, GER & JN SMITH, BIOCHEM J 102: 504 (1967). /FROM TABLE/
Antidote
1) ESTABLISH CLEAR AIRWAY & TISSUE OXYGENATION BY ASPIRATION OF SECRETIONS & IF NECESSARY, BY ASSISTED PULMONARY VENTILATION WITH OXYGEN. IMPROVE TISSUE OXYGENATION AS MUCH AS POSSIBLE BEFORE ADMINISTERING ATROPINE TO MINIMIZE THE RISK OF VENTRICULAR FIBRILLATION. /CARBAMATES, CHOLINESTERASE INHIBITORS/|2) ADMIN ATROPINE SULFATE IV, OR IM IF IV INJECTION IS NOT POSSIBLE... IN MODERATELY SEVERE POISONING: ADULT DOSAGE, INCLUDING CHILDREN OVER 12 YR: 0.4-2.0 MG REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED (TACHYCARDIA, FLUSHING, DRY MOUTH, MYDRIASIS). MAINTAIN ATROPINIZATION BY REPEATED DOSES FOR 2-12 HR, OR LONGER, DEPENDING ON SEVERITY OF POISONING... DOSAGE FOR CHILDREN UNDER 12 YEARS: 0.05 MG/KG BODY WT REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED. MAINTAIN ATROPINIZATION WITH REPEATED DOSAGE OF 0.02-0.05 MG/KG. SEVERELY POISONED INDIVIDUALS MAY EXHIBIT REMARKABLE TOLERANCE TO ATROPINE; TWICE THE DOSES SUGGESTED ABOVE MAY BE NEEDED... /CARBAMATES, CHOLINESTERASE INHIBITORS/|3. PRALIDOXIME (PROTOPAM-AYERST, 2-PAM) IS OF DOUBTFUL VALUE IN POISONINGS BY CARBAMATE INHIBITORS OF CHOLINESTERASE. ATROPINE ALONE IS ALMOST ALWAYS AN ADEQUATE ANTIDOTE. PRALIDOXIME IS PROBABLY CONTRAINDICATED IN POISONINGS BY CARBARYL, SPECIFICALLY. IF VICTIM OF CARBAMATE POISONING EXHIBITS SEVERE MUSCLE WEAKNESS &/OR RESPIRATORY DEPRESSION, OR IF POISONING INVOLVES A COMBINATION OF CARBAMATE & ORGANOPHOSPHATE, A DILUTE SOLUTION OF PRALIDOXIME (TOTAL DOSE IN 250 ML 5% GLUCOSE SOLN) MAY BE GIVEN CAUTIOUSLY IV. THE INFUSION SHOULD BE TERMINATED IF PATIENT'S CONDITION WORSENS. PRALIDOXIME DOSAGE: ADULTS, 1.0 G; FOR CHILDREN UNDER 12 YR, 20-50 MG/KG. 4. OBSERVE TREATED PATIENTS CLOSELY AT LEAST 24 HR TO INSURE THAT SYMPTOMS (POSSIBLY PULMONARY EDEMA) DO NOT RECUR AS ATROPINIZATION WEARS OFF. IN VERY SEVERE POISONINGS, METABOLIC DISPOSITION OF TOXICANT MAY REQUIRE SEVERAL HR OR DAYS DURING WHICH ATROPINIZATION MUST BE MAINTAINED. /CARBAMATES, CHOLINESTERASE INHIBITORS/|5. BATHE & SHAMPOO VICTIM WITH SOAP & WATER IF THERE IS ANY CHANCE THAT SKIN & HAIR ARE CONTAMINATED. 6. IF PESTICIDE HAS BEEN INGESTED IN QUANTITY SUFFICIENT TO CAUSE POISONING, EMPTY THE STOMACH & INTESTINE. A. IF VICTIM IS ALERT & RESPIRATION IS NOT DEPRESSED, GIVE SYRUP OF IPECAC, FOLLOWED BY 1-2 GLASSES OF WATER TO INDUCE VOMITING; ADULTS (INCLUDING CHILDREN OVER 12), 30 ML; CHILDREN (UNDER 12 YR), 15 ML. CAUTION: OBSERVE VICTIM CLOSELY AFTER ADMIN IPECAC, IF CONSCIOUSNESS LEVEL DECLINES, OR IF VOMITING HAS NOT OCCURRED IN 15 MIN, PROCEED IMMEDIATELY TO INTUBATE THE STOMACH. FOLLOWING EMESIS, HAVE VICTIM DRINK A SUSPENSION OF /PRC: 30 G ACTIVATED CHARCOAL IN 3-4 OZ OF WATER (CHILDREN), 100 G IN 8-10 OZ OF WATER (ADULTS)/...TO BIND TOXICANT REMAINING IN THE GI TRACT. /CARBAMATES, CHOLINESTERASE INHIBITORS/|For more Antidote and Emergency Treatment (Complete) data for PHENYL METHYLCARBAMATE (6 total), please visit the HSDB record page.
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Production
(1972) NEGLIGIBLE|(1975) No Data
Manufacturing Info
Carbamic acid, N-methyl-, phenyl ester: INACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.|WHEN MIXED WITH N-OCTYLBICYCLOHEPTENEDICARBOXIMIDE, PIPERONYLBUTOXIDE &/OR OCTACHLORODIPROL ETHER, IT IS USED AS BROAD-SPECTRUM INSECTICIDE.|ALKYL N-PHENYLCARBAMATE HERBICIDES ARE USED IN COMBINATION WITH PHENYL-ALKYLCARBAMATE OR N,N-DIALKYLCARBAMATE HERBICIDES FOR INCR OR PROLONGING HERBICIDAL ACTIVITY OR ALTERING SPECTRUM OF HERBICIDAL ACTIVITY.|EITHER 3,4-DICHLOROPROPIONANILIDE OR PHENYL METHYLCARBAMATE APPLIED TO SOILS @ (300 & 50 G/10 ACRE, RESPECTIVELY) HAD LITTLE ACTIVITY; IN COMBINATION THEY COMPLETELY CONTROLLED WEEDS.
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10. Toltal 9 Suppliers View more
Factory Supply Phenyl N-methylcarbamate
Amitychem Corporation
 1YR   China
Tel: Update Time:2023/06/28
inquire
Methylcarbamic acid phenyl ester
Dayang Chem (Hangzhou) Co., Ltd.
 1YR   China
Tel: Update Time:2024/06/17
inquire
Phenyl methylcarbamate
Alfa Chemistry
 1YR   United States
Tel: Update Time:2024/09/23
inquire
Phenyl methylcarbamate
BOC Sciences
  United States
Tel: Update Time:2023/06/30
inquire
Phenyl methylcarbamate
Nanjing Chemlin Chemical Co., Ltd.
  China
Tel: Update Time:2024/03/04
inquire
11. Realated Product Infomation
 
1. Names and Identifiers
2. Properties
3. Use and Manufacturing
4. Safety and Handling
5. Msds
6. Synthesis Route
7. Precursor and Product
8. Computational chemical data
9. Other Information
10. Toltal 9 Suppliers
11. Realated Product Infomation
 
 
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