Encyclopedia / Pharmaceutical Intermediates / Organic Intermediate

N-NITROSOPIPERIDINE

CAS：100-75-4
MW:114.15
MF：C5H10N2O

Light yellow oil or liquid. May be a carcinogen.

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Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
NMR Spectrum
Other Information
Computational chemical data
Realated Product Infomation

1. Names and Identifiers

1.1 Name: N-NITROSOPIPERIDINE

1.2 Synonyms: 1-Nitrosopiperidine; 1-nitrosopiperidine solution; EINECS 202-886-6; MFCD00023652; NITROSOPIPERIDINE; N-NITROSO-4-PIPERIDINE; N-NITROSOAPERIDINE; N-NITROSOPIPERIDINE, 1X1ML, MEOH, 5000UG /ML; Piperdine, 1-nitroso-; Piperidine, 1-nitroso-; rcrawastenumberu179; tl266;

1.3 CAS No.: 100-75-4

1.4 CID: 7526

1.5 EINECS: 202-886-6

1.6 Molecular Formula: C5H10N2O

1.7 Inchi: InChI=1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2

1.8 InChkey: UWSDONTXWQOZFN-UHFFFAOYSA-N

1.9 Canonical Smiles: C1CCN(CC1)N=O

1.10 Isomers Smiles: C1CCN(CC1)N=O

2. Properties

2.1 Solubility: 76.48g/L(24 ºC)

2.2 Appearance: N-nitrosopiperidine appears as light yellow oil or liquid. May be a carcinogen.

2.3 Storage: 2-8°C

2.4 Carcinogenicity: N-Nitrosopiperidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

2.5 Chemical Properties: light yellow oily liquid

2.6 Color/Form: YELLOW OIL
Pale yellow

2.7 pKa: -3.18±0.20(Predicted)

2.8 Water Solubility: In water, 7.65X10+4 mg/L at 24 deg C

2.9 Spectral Properties: MAX ABSORPTION: 354 NM (LOG E= 1.91); 366 NM (LOG E= 2.04); 377 NM (LOG E= 2.00)
INDEX OF REFRACTION: 1.4933 @ 18 DEG C/D
Max absorption in water 235 and 337 nm (E=837 and 6.4).

2.10 Stability: Stable. Combustible. Incompatible with strong oxidizing agents.

2.11 StorageTemp: 2-8°C

3. Use and Manufacturing

3.1 Definition: ChEBI: A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodum nitrite.

3.2 Description: light yellow oily liquid N-Nitrosopiperidine is a clear, yellow, oily liquid.ChEBI: A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sod um nitrite.Light yellow oil or liquid. May be a carcinogen.

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3.3 General Description: Light yellow oil or liquid. May be a carcinogen.

3.4 Potential Exposure: N-Nitrosopiperidine is found in somefoods and tobacco smoke. Used as a research chemical.

3.5 Shipping: UN2810 Toxic liquids, organic, n.o.s., HazardClass: 6.1; Labels: 6.1-Poisonous materials, Technical NameRequired. UN3082 Environmentally hazardous substances,liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardousmaterial, Technical Name Required

3.6 Usage: A carcinogenic nitrosocompound.

4. Safety and Handling

4.1 Octanol/Water Partition Coefficient: log Kow= 0.36

4.2 Fire Hazard: Flash point data are not available for N-NITROSOPIPERIDINE, but N-NITROSOPIPERIDINE is probably combustible.

4.3 Other Preventative Measures: PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide additional protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synthesis & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Vertical laminar-flow biological safety cabinets may be used for containment of in vitro procedures ... provided that the exhaust air flow is sufficient to provide an inward air flow at the face opening of the cabinet, & contaminated air plenums that are under positive pressure are leak-tight. Horizontal laminar-flow hoods or safety cabinets, where filtered air is blown across the working area towards the operator, should never be used. ... Each cabinet or fume cupboard to be used ... should be tested before work is begun (eg, with fume bomb) & label fixed to it, giving date of test & avg air-flow measured. This test should be repeated periodically & after any structural changes. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Principles that apply to chem or biochem lab also apply to microbiological & cell-culture labs ... Special consideration should be given to route of admin. ... Safest method of admin volatile carcinogen is by injection of a soln. Admin by topical application, gavage, or intratracheal instillation should be performed under hood. If chem will be exhaled, animals should be kept under hood during this period. Inhalation exposure requires special equipment. ... Unless specifically required, routes of admin other than in the diet should be used. Mixing of carcinogen in diet should be carried out in sealed mixers under fume hood, from which the exhaust is fitted with an efficient particulate filter. Techniques for cleaning mixer & hood should be devised before expt is begun. When mixing diets, special protective clothing &, possibly, respirators may be required. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": When ... admin in diet or applied to skin, animals should be kept in cages with solid bottoms & sides & fitted with a filter top. When volatile carcinogens are given, filter tops should not be used. Cages which have been used to house animals that received carcinogens should be decontaminated. Cage-cleaning facilities should be installed in area in which carcinogens are being used, to avoid moving of ... contaminated /cages/. It is difficult to ensure that cages are decontaminated, & monitoring methods are necessary. Situations may exist in which the use of disposable cages should be recommended, depending on type & amt of carcinogen & efficiency with which it can be removed. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": To eliminate risk that ... contamination in lab could build up during conduct of expt, periodic checks should be carried out on lab atmospheres, surfaces, such as walls, floors & benches, & ... interior of fume hoods & airducts. As well as regular monitoring, check must be carried out after cleaning-up of spillage. Sensitive methods are required when testing lab atmospheres for chem such as nitrosamines. Methods ... should ... where possible, be simple & sensitive. ... /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Rooms in which obvious contamination has occurred, such as spillage, should be decontaminated by lab personnel engaged in expt. Design of expt should ... avoid contamination of permanent equipment. ... Procedures should ensure that maintenance workers are not exposed. ... Particular care should be taken to avoid contamination of drains or ventilation ducts. In cleaning labs, procedures should be used which do not produce aerosols or dispersal of dust, ie, wet mop or vacuum cleaner equipped with high-efficiency particulate filter on exhaust, which are avail commercially, should be used. Sweeping, brushing & use of dry dusters or mops should be prohibited. ... Contaminated cleaning materials should not be re-used. ... If gowns or towels are contaminated, they should not be sent to laundry, but ... decontaminated or burnt, to avoid any hazard to laundry personnel. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Doors leading into areas where carcinogens are used ... should be marked distinctively with appropriate labels. Access should be ... limited to persons involved in expt. ... A prominently displayed notice should give the name of the Scientific Investigator or other person who can advise in an emergency & who can inform others (such as firemen) on the handling of carcinogenic substances. /Chemical Carcinogens/

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4.4 Cleanup Methods: PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms. ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal. ... The plastic bag should be sealed immediately. ... The sealed bag should be labelled properly. ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated. ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/
Nitrosamine residues generated in laboratory research or accidental spills in research laboratories and diluted to concn of 10 mg/l or less are rapidly reduced to innocuous amines, ammonia, or alcohols by aluminum-nickel alloy powder and aqueous alkali. The method is applicable to a variety of media (water, mineral oil, olive oil, dimethylsulfoxide, soln of agar gel) but is not recommended for use with nitrosamines in acetone or dichloromethane because reactions are slow and incomplete. After the reduced reaction mixture is filtered, the liquid is disposed of by pouring it over sufficient absorbent material to convert it to a solid waste for incineration. /Nitrosamines/
Decontamination of N-nitrosamines contaminated glassware /was described/. /N-nitrosamines/

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4.5 DisposalMethods: Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U179, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 deg C and a residence time of 0.1 to 2 seconds. A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 deg C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 deg C and residence times of seconds for liquids and gases, and longer for solids.
PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... Summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": Total destruction ... by incineration may be only feasable method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable. ... Most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/
PRECAUTIONS FOR "CARCINOGENS": ... Small quantities of ... some carcinogens can be destroyed using chem reactions ... but no general rules can be given. ... As a general technique ... treatment with sodium dichromate in strong sulfuric acid can be used. The time necessary for destruction ... is seldom known ... but 1-2 days is generally considered sufficient when freshly prepd reagent is used. ... Carcinogens that are easily oxidizable can be destroyed with milder oxidative agents, such as saturated soln of potassium permanganate in acetone, which appears to be a suitable agent for destruction of hydrazines or of compounds containing isolated carbon-carbon double bonds. Concn of 50% aqueous sodium hypochlorite can also be used as an oxidizing agent. /Chemical Carcinogens/
Destruction of N-nitrosamines in lab wastes using denitrosation with hydrobromic acid /was described/. /N-Nitrosamines/
BECAUSE N-NITROSODIETHYLAMINE IS CHEMICALLY STABLE UNDER USUAL CONDITIONS, DISPOSAL IS BEST CARRIED OUT BY INCINERATION. FOR INCINERATION OF LIQ WASTES, SOLN SHOULD BE NEUTRALIZED IF NECESSARY, FILTERED TO REMOVE SOLIDS, & PUT IN CLOSED POLYETHYLENE CONTAINERS FOR TRANSPORT. ALL EQUIPMENT SHOULD BE THOROUGHLY RINSED WITH SOLVENT, WHICH SHOULD THEN BE ADDED TO LIQ WASTE FOR INCINERATION. GREAT CARE SHOULD BE EXERCISED TO PREVENT CONTAMINATION OF OUTSIDE OF SOLVENT CONTAINER. IF POSSIBLE, SOLID WASTES SHOULD BE INCINERATED; IF THIS IS NOT POSSIBLE, SOLID WASTES FROM REACTION MIXT THAT MAY CONTAIN N-NITROSODIETHYLAMINE SHOULD BE EXTRACTED & EXTRACTS ADDED TO LIQ WASTE. ...ANY RAGS, PAPER, & SUCH THAT MAY BE CONTAMINATED SHOULD BE INCINERATED. CONTAMINATED SOLID MATERIALS SHOULD BE ENCLOSED IN SEALED PLASTIC BAGS THAT ARE LABELED CANCER-SUSPECT AGENT & WITH NAME & AMT OF CARCINOGEN. BAGS SHOULD BE STORED IN WELL-VENTILATED AREA UNTIL THEY ARE INCINERATED. /N-NITROSODIETHYLAMINE, ALSO APPLICABLE TO OTHER ALKYLNITROSAMINES/
Destruction of N-nitrosamines in lab wastes using potassium permanganate /was described/. /N-Nitrosamines/
Destruction of N-nitrosamines in lab wastes using nickel-aluminum alloy in potassium hydroxide solution /was described/. /N-Nitrosamines/
(1) Nitrosamines may be reduced to the corresponding amine by using nickel-aluminum (Ni-Al) alloy in dilute base. The nitrosamines were completely degraded (99.9%) and only the amines (RR'NH) were found in the final reaction mixtures. No traces (generally 99.5%). The products of this reaction have not been determined. (3) Nitrosamines may be destroyed by using hydrogen bromide (HBr) in glacial acetic acid. The nitrosamines were completely destroyed (>99%) and the products were presumably the corresponding amines. All of these procedures were validated by an international collaborative study. /Nitrosamines/

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4.6 Safety Profile: Confirmed carcinogenwith experimental carcinogenic,neoplastigenic, and tumorigenic data. Poisonby ingestion, intravenous, and subcutaneousroutes. An experimental teratogen. Humanmutation data reported. When heated todecomposition it emits toxic fumes of NOx.See also N-NITROSO COMPOUNDS.

4.7 Incompatibilities: Nitrated organics range from slight tostrong oxidizing agents. If mixed with reducing agents,including hydrides, sulfides and nitrides, they may begin avigorous reaction. Reaction with aliphatic amines canrelease carcinogenic nitrosamines. Incompatible with oxidizers(chlorates, nitrates, peroxides, permanganates, perchlorates,chlorine, bromine, fluorine, etc.); contact may causefires or explosions. Keep away from alkaline materials,strong bases, strong acids, oxoacids, epoxides. Light andUV may cause decomposition

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4.8 Protective Equipment and Clothing: PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent ... Safety pipettes ... for all pipetting. ... In animal laboratory ... protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators ... when working with particulates or gases, & disposable plastic aprons ... gowns ... /should be/ of distinctive color. /Chemical carcinogens/
Wear nitrile rubber gloves, protective laboratory coat, self-contained breathing apparatus, eye protection and protective shoes. /Nitrosamines/

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4.9 Report: NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 287.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 287.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 28 ,1982,p. 151.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Community Right-To-Know List. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

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4.10 Safety: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also N-NITROSO COMPOUNDS.
Hazard Codes of N-Nitrosopiperidine (CAS NO.100-75-4): T,F
Risk Statements: 25-40-39/23/24/25-23/24/25-11
R11:Highly flammable.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R25 :Toxic if swallowed.
R39:Danger of very serious irreversible effects.
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 53-23-26-36/37/39-45-36/37-16-9
S9:Keep container in a well-ventilated place.
S16:Keep away from sources of ignition.
S23:Do not breathe vapour.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.

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4.11 Specification: N-Nitrosopiperidine ,its cas register number is 100-75-4. It also can be called Piperidine, 1-nitroso- ; Nitrosopiperidine ;and 1-nitrosopiperidine . It may react with strong oxidizing agents, especially peroxyacids.

4.12 Toxicity: LD50 orl-rat: 200 mg/kg ZEKBAI 69,103,67

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Carcinogenicity, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H351 Suspected of causing cancer
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

13C NMR : Predict

1H NMR : Predict

Predict 1H proton NMR

7. Synthesis Route

100-75-4Total: 26 Synthesis Route

94-62-2 275 Suppliers

100-75-4 23 Suppliers

110-89-4

100-75-4 23 Suppliers

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8. Precursor and Product

precursor:

2213-43-6

94-62-2

6091-45-8

626-67-5

7119-94-0

766-09-6

product:

2213-43-6

55556-85-9

1055-23-8

7664-41-7

84914-82-9

14585-46-7

5824-73-7

55556-91-7

7119-94-0

55556-93-9

9. Computed Properties

Molecular Weight：114.15g/mol
Molecular Formula：C₅H₁₀N₂O
Compound Is Canonicalized：True
XLogP3-AA：114.079312947
Monoisotopic Mass：114.079312947
Complexity：78.5
Rotatable Bond Count：0
Hydrogen Bond Donor Count：0
Hydrogen Bond Acceptor Count：3
Topological Polar Surface Area：32.7
Heavy Atom Count：：8
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADccBjIAAAAAAAAAAAAAAAAAAAAAAAAAAsAAAAAAAAAAAAAAAAHAAMAAAACADBAAQAAAIAAAABAAAAAAAAAAAAAAAQAAAIAAAAAAIAgAAEAAAAAACAAAAQAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10.Other Information

Chemical Properties: light yellow oily liquid

Chemical Properties: N-Nitrosopiperidine is a clear, yellow, oily liquid.

Uses: A carcinogenic nitrosocompound.

Definition: ChEBI: A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sod um nitrite.

Synthesis Reference(s): Chemical and Pharmaceutical Bulletin, 36, p. 459, 1988 DOI: 10.1248/cpb.36.459

General Description: Light yellow oil or liquid. May be a carcinogen.

Air & Water Reactions: Water soluble.

Reactivity Profile: N-NITROSOPIPERIDINE may react with strong oxidizing agents, especially peroxyacids. .

Health Hazard: ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOPIPERIDINE emits highly toxic fumes.

Fire Hazard: Flash point data are not available for N-NITROSOPIPERIDINE, but N-NITROSOPIPERIDINE is probably combustible.

Safety Profile: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Potential Exposure: N-Nitrosopiperidine is found in some foods and tobacco smoke. Used as a research chemical.

Carcinogenicity: N-Nitrosopiperidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping: UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Incompatibilities: Nitrated organics range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction. Reaction with aliphatic amines can release carcinogenic nitrosamines. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Light and UV may cause decomposition

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Waste Disposal: Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Under 40 CFR 261.5 small quantity generators of this waste may qualify for partial exclusion from hazardous waste regulations.

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