PROMECARB

CAS：2631-37-0
MW:207.273
MF：C12H17NO2

Almost odorless, colorless crystalline solid. Used as a non-systemic contact insecticide. Not for sale or use in the USA.

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Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
NMR Spectrum
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: PROMECARB

1.2 Synonyms: (3-methyl-5-isopropylphenyl)-n-methylcarbamat; 3-Isopropyl-5-methylphenyl methylcarbamate; 3-Isopropyl-5-methylphenyl N-methylcarbamate; 3-isopropyl-5-methylphenyln-methylcarbamate; 3-methyl-5-(1-methylethyl)phenolmethylcarbamate; 3-methyl-5-(1-methylethyl)-phenomethylcarbamate; 3-methyl-5-(1-methylethyl)phenylmethylcarbamate; 3-Methyl-5-i-propylphenyl N-methylcarbamate; 3-methyl-5-isopropyln-methylcarbamate; 3-Methyl-5-Isopropylphenyl methylcarbamate; 3-Methyl-5-isopropylphenyl N-methylcarbamate; Carbamic acid, methyl-, m-cym-5-yl ester; Carbamult; EP 316; ITC; m-Cym-5-yl methylcarbamate; Minacide; Morton EP-316; NSC 35378; Phenol, 3-methyl-5-(1-methylethyl)-, 1-(N-methylcarbamate); Phenol, 3-methyl-5-(1-methylethyl)-, methylcarbamate; Sch 34615; Schering 34615;

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1.3 CAS No.: 2631-37-0

1.4 CID: 17516

1.5 EINECS: 220-113-0

1.6 Molecular Formula: C12H17NO2

1.7 Inchi: InChI=1S/C12H17NO2/c1-8(2)10-5-9(3)6-11(7-10)15-12(14)13-4/h5-8H,1-4H3,(H,13,14)

1.8 InChkey: DTAPQAJKAFRNJB-UHFFFAOYSA-N

1.9 Canonical Smiles: CC1=CC(=CC(=C1)OC(=O)NC)C(C)C

1.10 Isomers Smiles: CC1=CC(=CC(=C1)OC(=O)NC)C(C)C

2. Properties

2.1 Solubility: 92mg/L(room temperature)

2.2 AnalyticLaboratory Methods: PRODUCT ANALYSIS IS BY HYDROLYSIS, ISOLATION OF METHYLAMINE; WHICH IS ESTIMATED BY TITRATION. RESIDUES MAY BE DETERMINED BY GLC OR BY MEASUREMENT OF 5-METHYL-M-CUMENOL PRODUCED ON HYDROLYSIS.

2.3 Appearance: Crystalline

2.4 Chemical Properties: Colorless, crystalline solid. Insoluble in water; soluble in alcohol.

2.5 Color/Form: COLORLESS CRYSTALLINE SOLID

2.6 Corrosivity: Non-corrosive

2.7 Odor: ALMOST ODORLESS

2.8 Physical: Almost odorless, colorless crystalline solid. Used as a non-systemic contact insecticide. Not for sale or use in the USA. (EPA, 1998)

2.9 pKa: 12.37±0.46(Predicted)

2.10 Water Solubility: 92mg/L(room temperature)

2.11 Spectral Properties: Intense mass spectral peaks: 135 m/z (100%), 150 m/z (70%), 91 m/z (25%), 58 m/z (23%)

2.12 Stability: Hydrolyzed in alkalies

2.13 StorageTemp: 0-6°C

3. Use and Manufacturing

3.1 Description

Colorless, crystalline solid. Insoluble in water; soluble in alcohol. Promecarb is a colorless, odorless, crystalline solid

Almost odorless, colorless crystalline solid. Used as a non-systemic contact insecticide. Not for sale or use in the USA. (EPA, 1998)

Almost odorless, colorless crystalline solid. Used as a non-systemic contact insecticide. Not for sale or use in the USA. (EPA, 1998)|Promecarb is an alkylbenzene.

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3.2 General Description: Almost odorless, colorless crystalline solid. Used as a non-systemic contact insecticide. Not for sale or use in the USA.

3.3 GHS Classification: Signal: Danger
GHS Hazard Statements
H301: Toxic if swallowed [Danger Acute toxicity, oral]
H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes
P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501

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3.4 Methods of Manufacturing: REACTION OF 3-ISOPROPYL-5-METHYLPHENOL & METHYL ISOCYANATE|/PROMECARB IS/ MADE BY REACTION OF 5-ISOPROPYL-M-CRESOL WITH METHYL ISOCYANATE ... .

3.5 Potential Exposure: A potential danger to those involvedin the manufacture, formulation or application of this non-systemic contact insecticide.

3.6 Shipping: UN2811 Toxic solids, organic, n.o.s., HazardClass: 6.1; Labels: 6.1-Poisonous materials, TechnicalName Required.

3.7 Usage: Insecticide.

3.8 Waste Disposal: Small quantities: treat withalkali and then bury. Large quantities: incineration .In accordance with 40CFR165, follow recommendationsfor the disposal of pesticides and pesticide containers.Must be disposed properly by following package labeldirections or by contacting your local or federal environ-mental control agency, or by contacting your regionalEPA office. PROMECARBSupplier

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4. Safety and Handling

4.1 Octanol/Water Partition Coefficient: log Kow= 3.10 (measured)

4.2 Fire Hazard: (Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Hydrolyzed by alkalis. Stable. No changes observed on storage for 140 hours at122F.

4.3 Other Preventative Measures: Carefully wash with soap & water any parts or the skin contracted with promecarb.

4.4 DisposalMethods: Hydrolysis: Promecarb should be treated with alkali and then buried. Recommendable methods: Incineration & landfill.

4.5 Formulations/Preparations: EMULSIFIABLE CONCENTRATE (200 G ACTIVE INGREDIENT/L); WETTABLE POWDER (375 AND 500 G/KG).

4.6 Incompatibilities: Alkalis.

4.7 Report: EPA Extremely Hazardous Substances List.

4.8 Safety: Poison by ingestion, intraperitoneal, intravenous, intramuscular, and subcutaneous routes. Moderately toxic by skin contact. An insecticide. When heated to decomposition it emits toxic fumes of NO_x. See also CARBAMATES.
Hazard Codes T,N
Risk Statements 25-50/53
R25 :Toxic if swallowed.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements 24-37-45-60-61
S24:Avoid contact with skin.
S37:Wear suitable gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR 2757
RTECS FB8050000
HazardClass 6.1(a)
PackingGroup II

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4.9 Specification: 1.Reactivity Profile: Promecarb is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
2.Health Hazard: Promecarb is highly toxic by ingestion and is absorbed through the intact skin. It is a reversible cholinesterase inhibitor and its effects are related to action on the nervous sysem.
3.Fire Hazard: (Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Hydrolyzed by alkalis. Stable. No changes observed on storage for 140 hours at122F.

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4.10 Toxicity: Oral-Rat? LD50: 35 mg/kg; Oral-Mouse LD50: 16 mg/kg

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/\u2026 P321 Specific treatment (see ... on this label). P330 Rinse mouth. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

13C NMR : Predict

1H NMR : Predict

Mass spectrum (electron ionization)

7. Computed Properties

Molecular Weight：207.273g/mol
Molecular Formula：C₁₂H₁₇NO₂
Compound Is Canonicalized：True
XLogP3-AA：207.125928785
Monoisotopic Mass：207.125928785
Complexity：216
Rotatable Bond Count：3
Hydrogen Bond Donor Count：1
Hydrogen Bond Acceptor Count：2
Topological Polar Surface Area：38.3
Heavy Atom Count：：15
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADceByMAAAAAAAAAAAAAAAAAAAAAAAAAAwAAAAAAAAAAABAAAAHgAQAAAADQSAmAQyDoLABACIAiBCGAACCAAgIAAAiIAOCIkMJiKEMRqIMiAkwhEIqAeAwPAOgAADAAAAAAAAAAYAAAAAAAAAAAAAAA==

8.Other Information

Storage Conditions: REACTION OF 3-ISOPROPYL-5-METHYLPHENOL & METHYL ISOCYANATE|/PROMECARB IS/ MADE BY REACTION OF 5-ISOPROPYL-M-CRESOL WITH METHYL ISOCYANATE ... .

Collision Cross Section: 150.39 ?2 [M+H]+

Experimental Properties: Hydrolyzed by strong acids and alkalis|Henry's Law Constant= 9.0X10-8 atm-cu m/mole (est).

Reactive Group: Carbamates

Reactivity Profile: PROMECARB is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.

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Storage features: The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Disposal Methods: Hydrolysis: Promecarb should be treated with alkali and then buried. Recommendable methods: Incineration & landfill.

Fire Hazards: (Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Hydrolyzed by alkalis. Stable. No changes observed on storage for 140 hours at122F. (EPA, 1998)

Nonfire Spill Response: (Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard areas and deny entry. Stay upwind and keep out of low areas. Do not touch spilled material or breathe the dusts, vapors, or fumes from burning materials. Use water spray to reduce vapors. Do not handle broken packages without protective equipment. Wash away any material that may have contacted the body with soap and water. Take up small spills with sand or other noncombustible absorbent material and place in containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Dike far ahead of large spills for later disposal. (EPA, 1998)

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Personal Protective Equipment: For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|Wear protective clothing when working with undiluted preparation.

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Preventive Measures: Carefully wash with soap & water any parts or the skin contracted with promecarb.

Pollution Sources: Promecarb is used as a non-systemic contact insecticide against lepidopterous pests and leaf miners of fruits(1). Insecticidal applications of promecarb release the compound directly into the environment(SRC).

Environmental Fate: TERRESTRIAL FATE: The N-methylcarbamate pesticides (of which promecarb is a member) are generally biodegradable and of low soil persistence(1). Chemical degradation of promecarb in moist soil is expected to proceed via hydrolysis. The aqueous hydrolysis half-life has been estimated to be 1.2 days at 25 °C and pH 7; the hydrolysis rate is expected to increase under alkaline conditions, but decrease with acidity in soil. Promecarb is expected to have low to moderate soil mobility which suggests that some leaching may be possible. Leaching in neutral and alkaline soils may not be significant, however, due to concurrent hydrolysis(SRC).|AQUATIC FATE: Hydrolysis appears to be an important degradation process for promecarb in water. The aqueous hydrolysis half-life has been estimated to be 1.2 days at 25 °C and pH 7(1); the hydrolysis rate is expected to increase under alkaline conditions, but may decrease significantly in acidic in natural waters.|ATMOSPHERIC FATE: Based upon a vapor pressure of 0.00003 mm Hg at 25 °C(1), promecarb can be expected to exist in both the gas phase and particulate phase in the ambient atmosphere(2,SRC). Gas phase promecarb is expected to degrade rapidly in air by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in an average atmosphere has been estimated to be about 5 hr. Particulate phase promecarb may be physically removed from air via wet and dry deposition(SRC).

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Abiotic Degradation: The rate constant for the vapor phase reaction of promecarb with photochemically produced hydroxyl radicals has been estimated to be 77X10-12 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 5 hr at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Promecarb is hydrolyzed by strong acids and bases and is incompatible with alkaline preparations(2). The aqueous hydrolysis half-life of promecarb at 25 °C and pH 7 has been estimated to be 1.2 days(3). At 22 °C, promecarb is reported to be stable at pH 5, but 50% loss occurs in 5.2 days at pH 7 and 50% loss occurs in 1.5 days at pH 9(4).

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Bioconcentration: Based upon a water solubility of 91 ppm at 25 °C(1) and a measured log Kow of 3.10(2), the bioconcentration factor (BCF) for promecarb can be estimated to be 49 and 134, respectively, from recommended regression- derived equations(3,SRC). These BCF estimates suggest a low potential for bioconcentration(SRC).

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Mobility: 302.00 L/kg|Utilizing soil thin-layer chromatography, the Rf value of promecarb in Hagerstown silty clay loam soil was measured to be 0.34 which is suggestive of low to moderate soil mobility(1). Based upon a water solubility of 91 ppm at 25 °C(2) and a measured log Kow of 3.10(3), the Koc value for promecarb can be estimated to range from 365 to 1240 from various regression-derived equations(4,SRC). These estimated Koc values also indicate low to medium soil mobility(5).

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Volatilization: Based upon water solubility of 91 ppm and a vapor pressure of 0.00003 mm Hg at 25 °C(1), the Henry's Law Constant for promecarb can be estimated to be 9.0X10-8 atm-cu m/mole(SRC). This value of Henry's Law Constant indicates that volatilization from water is not significant(2).

Food Survey Values: Analysis by the US Food and Drug Administration of 7,893 samples of domestic and imported fruits and 165 ready to eat fruit composites of the Total Diet Study for fiscal years 1970-1976 found promecarb in only one large fruit sample(1).

Human Exposure: Occupational exposure to promecarb may be possible through dermal contact and inhalation to workers involved with applying or formulating promecarb pesticides. Exposure may be possible through consumption of fruit products treated with promecarb pesticides. (SRC)

Absorption: ... /CARBAMATE INSECTICIDES/ ARE RAPIDLY METABOLIZED, 80% OF DOSE BEING ELIMINATED IN URINE, MAINLY AS SULFATE OR GLUCURONIDE CONJUGATE, WITHIN 24 HR; 0.5 TO 1.5% IS FOUND IN FECES, 0.1 TO 1.0% IN THE MILK. /CARBAMATES/|In order to learn why cholinesterase remains inhibited longer in workers exposedto promecarb than in those exposed to propoxur, dogs were injected im or iv with approximately equitoxic doses of the compounds. It required 3 full days for cholinesterase activity to return to normal in a dog that received promecarb intramuscularly at a rate of 60 mg/kg, but recovery of cholinesterase activity was rapid after doses of propoxur sufficient to cause convulsions and marked ataxia. However, inhibition of cholinesterase activity was transient following intravenous administration of promecarb. It was concluded that prolonged inhibition of cholinesterase activity in days following im injection was the result of slow, continuing absorption and that, by extension, prolonged inhibition in workers has the same cause.|Penetration of the blood-brain barrier by the carbamates is insignificant; for this reason, fewer CNS symptoms occur. /Carbamate pesticides/

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Metabolism: Promecarb was rapidly metabolized and eliminated when administered orally to rats. By 96 hours after administration, over 90% had been recovered from the urine and feces, mainly the former. Promecarb equivalent radioactivity in the tissues did not exceed 0.02 ppm.|(5-(14)C)Promecarb was administered orally to male Sprague Dawley rats. Within 4 days, about 88% of the dose was eliminated in the urine. In addition to isothymol, there were unidentified metabolites. Hydrolysis with glucuronidase indicated the conjugation of isothymol with glucuronic acid. Other conjugates present were not identified.|Promecarb was applied to soil and then corn seedlings were planted. Analyses of stem and leaves of the plants indicated the presence of isothymol and four unidentified metabolites as early as 15 days after application.|Spontaneous hydrolysis of the carbamate-cholinesterase complex occurs in vivo, leading to the disappearance of clinical effects within 24 hr. /Carbamate pesticides/

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First Aid: Note: Promecarb is a cholinesterase inhibitor. Signs and Symptoms of Promecarb Exposure: Acute exposure to promecarb usually leads to a cholinergic crisis. Signs and symptoms may include increased salivation, profuse sweating, lacrimation (tearing), spontaneous defecation, and spontaneous urination. Pinpoint pupils, blurred vision, headache, tremors, muscle twitching, slight paralysis, and loss of muscle coordination may occur. Malaise, mental confusion, convulsions, unconsciousness, and coma may also be noted. Gastrointestinal effects include nausea, vomiting, diarrhea, and abdominal pain. Bradycardia (slow heart rate) occurs frequently. Pulmonary edema, dyspnea (shortness of breath), labored breathing, respiratory depression, or respiratory arrest may also occur. Emergency Life-Support Procedures: Acute exposure to promecarb may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to promecarb. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Rush to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to promecarb. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove and isolate contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas thoroughly with water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Rush to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of promecarb is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of promecarb may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Rush to a health care facility. (EPA, 1998)

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Human Toxicity Excerpts: Symptomatology: 1. Nausea, vomiting, abdominal cramps, diarrhea & excessive salivation ... sweating. 2. Lassitude & weakness. 3. Rhinorrhea and sensation of tightness in chest may occur with inhalation exposure. 4. Blurring or dimness of vision. Miosis ... tearing, ciliary muscle spasm, loss of accommodation and ocular pain. None of these ... signs ... is dependable for diagnosis. Mydriasis may be seen ... . 5. Loss of muscle coordination, slurring of speech, fasciculation & twitching of muscles. 6. Difficulty in breathing, excessive secretions of saliva and of resp tract mucus, oronasal frothing, cyanosis, pulmonary rales & rhonchi, and hypertension. 7. ... Jerky movements, incontinence, convulsions and coma. 8. Death ... due to resp arrest of central origin, paralysis of resp muscles, intense bronchoconstriction or all three. /Carbaryl/|... MOST OF AROMATIC CARBAMATE ESTER INSECTICIDES HAVE LOW DERMAL TOXICITIES. /CARBAMATES/|Promecarb was tried on a village scale at the WHO Insecticide Testing Unit in Nigeria, in 1965. Its residual action against adult mosquitos was found very effective. Three spraymen spent 3 days spraying empty houses and then 3 more days spraying an inhabited village. They were under constant medical supervision. There were no complaints, and clinical examination failed to reveal any signs. All the 90 inhabitants of the sprayed village were examined clinically at least once within the fortnight after spraying. The only findings were discrete skin eruptions in two young men. These eruptions, of an obvious contact dermatitis type, caused moderate itching that was relieved by calamine lotion; they disappeared completely in 5 to 6 days. ... The plasma cholinesterase levels were studied among the spraymen and residents by the electrometric, spectrophotometric, and Acholest methods; a significant depression of activity was demonstrated by all three. The plasma cholinesterase activity of the three spraymen was measured daily. All showed depressions from the first day onward. During 3 days of consecutive spraying, the level of activity went steadily down in two of the three spraymen. On the last day of the operation, the plasma cholinesterase activity of one sprayman was about 40.% of its original level when measured by the spectrophotometric and Acholest methods. Three to four days after the end of exposure, plasma cholinesterase activity among the spraymen had not quite returned to the level measured before exposure, but it was normal in 5 days. Among the residents, there was a decrease of plasma cholinesterase activity to about 50% of the prespraying level a week after the end of the spraying operations One month later, there was a general rise, but the plasma cholinesterase levels were still far below the original values.|When tested for malaria control, promecarb caused cholinesterase inhibition amoung both sprayers and villagers but no signs or symptoms in either except for contact dermatitis in two male villagers.

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Mesh Entry Terms: 3-cym-5-yl methylcarbamate

Formulations: EMULSIFIABLE CONCENTRATE (200 G ACTIVE INGREDIENT/L); WETTABLE POWDER (375 AND 500 G/KG).

Manufacturing Info: The WHO Recommended Classification of Pesticides by Hazard identifies Promecarb (technical grade) as an active ingredient believed to be obsolete or discontinued for use as a pesticide.|WEST GERMAN PATENT 1,156,272; BRITISH PATENT 916,707|PROMECARB IS A NON-SYSTEMIC CONTACT INSECTICIDE EFFECTIVE AGAINST COLEOPTEROUS PESTS SUCH AS POST-EMBRYONIC STAGES OF LEPTINOTARSA DECEMLINEATA @ 450 G ACTIVE INGREDIENT/HECTARE, AGAINST LEPIDOPTEROUS PESTS AND LEAF MINERS OF FRUIT @ 50-100 G/L.|INCOMPATIBLE WITH ALKALINE PREPARATIONS.

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Use Classification: Agrochemicals -> Insecticides

9. Toltal 8 Suppliers View more

Nanjing Sunsure Chemical Technology Co., Ltd

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Crescent Chemical Co., Inc.

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10. Related Questions

: What is PROMECARB and how is it used?PROMECARB, also known as 3-isopropyl-5-methylphenyl-N-methylcarbamate, is a colorless and odorless crystal with a melting point of 87-88°C and a boiling point of 117°C (0.01×133.322Pa). It has a solub..

11. Realated Product Infomation

Promecarb-d3cas:1219799-11-7