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SELANK

CAS：129954-34-3
MW:751.887
MF：C33H57N11O9

Selank, with the chemical formula C33H57N11O9 and CAS registry number 129954-34-3, is a synthetic peptide compound known for its potential therapeutic effects. This peptide is derived from the naturally occurring peptide tuftsin and has been studied for its potential use in the treatment of anxiety, depression, and cognitive disorders. Selank is believed to modulate the activity of neurotransmitters in the brain, leading to a reduction in anxiety and improved cognitive function. It has also been shown to have anti-inflammatory and immune-modulating properties. Further research is ongoing to explore the full potential of Selank in various therapeutic applications.

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Names and ldentifier
Properties
Use and Manufacturing
Other Information
Computational chemical data
Related Questions

1. Names and Identifiers

1.1 Name: SELANK

1.2 Synonyms: CTK0F5879; H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH; L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-; L-Proline, L-threonyl-L-lysyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-prolylglycyl-; L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline; L-Threonyl-L-lysyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-prolylglycyl-L-proline; MONOACETATE; PL14736; Selanc; Selank peptid; Selank peptide; SelankAcetate; SLANK;

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1.3 CAS No.: 129954-34-3

1.4 CID: 11765600

1.5 EINECS: 232-660-2

1.6 Molecular Formula: C33H57N11O9

1.7 Inchi: InChI=1S/C33H57N11O9/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38)/t19-,20+,21+,22+,23+,24+,26+/m1/s1

1.8 InChkey: JTDTXGMXNXBGBZ-YVHUGQOKSA-N

1.9 Canonical Smiles: CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)N2CCCC2C(=O)NCC(=O)N3CCCC3C(=O)O)N)O

1.10 Isomers Smiles: C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N3CCC[C@H]3C(=O)O)N)O

2. Properties

2.1 Solubility: 略溶 (18 g/L) (25 oC),

2.2 pKa: 3.43±0.20(Predicted)

3. Use and Manufacturing

3.1 Description

Selank, with the chemical formula C33H57N11O9, has the CAS number 129954-34-3. It is a synthetic peptide that belongs to the class of nootropic drugs. Selank appears as a white powder with no distinct odor. Its basic structure consists of a sequence of amino acids attached to a peptide backbone. This compound is soluble in water. Selank is considered to be safe for use and has no known toxicity or side effects. It is commonly used as a cognitive enhancer and anxiolytic agent. Selank has been shown to have neuroprotective and anti-inflammatory effects. It is also known to modulate the levels of neurotransmitters in the brain, such as dopamine and serotonin. Overall, Selank is a versatile compound with potential applications in the field of neuroscience and mental health.

Applicable Fields

Neuroscience: Selank is primarily used in the field of neuroscience for its cognitive enhancing and anxiolytic properties. It has been shown to improve memory, attention, and learning abilities. The mechanism of action in this context involves the modulation of neurotransmitter levels and the promotion of neuroplasticity.

Mental Health: Selank is also used in the field of mental health to alleviate symptoms of anxiety and depression. It has been shown to have anxiolytic and antidepressant effects. The mechanism of action in this context involves the regulation of stress hormones and the modulation of neurotransmitter activity.

Storage

Conditions: Store in a cool and dry place.

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4. Computed Properties

Molecular Weight：751.887g/mol
Molecular Formula：C₃₃H₅₇N₁₁O₉
Compound Is Canonicalized：True
Exact Mass：-6.1
XLogP3-AA：751.43407244
Monoisotopic Mass：751.43407244
Complexity：1360
Rotatable Bond Count：19
Hydrogen Bond Donor Count：9
Hydrogen Bond Acceptor Count：12
Topological Polar Surface Area：322
Heavy Atom Count：：53
Defined Atom Stereocenter Count：7
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADcfB//AAAAAAAAAAAAAAAAAAAAWLFgAAAAAAAAAAAAAAAAAAAHgAQCAAACDzhgAYDCAPAAgAoAAGQPAAAAAEAAAAAAIGIAAACUBYAgCAUQAAGNgCQAAGYGQIAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

5.Other Information

Description: Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine (Item No. 16094) in mice. It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.

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Description: Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.

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7. Related Questions

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