Encyclopedia / Food Additives / Preservatives / Pharmaceutical Intermediates

Sodium benzoate

CAS：532-32-1
MW:144.10317
MF：C7H5NaO2

Sodium benzoate, with the chemical formula C7H5NaO2 and CAS registry number 532-32-1, is a compound commonly used as a food preservative. It is a white crystalline powder that is soluble in water. Sodium benzoate is known for its ability to inhibit the growth of bacteria, yeast, and mold, making it an effective preservative for a wide range of food and beverage products. It is often used in soft drinks, fruit juices, pickles, and condiments. In addition to its preservative properties, sodium benzoate is also used as a pH adjuster and flavoring agent in some products. While generally recognized as safe by regulatory authorities, some individuals may be sensitive to sodium benzoate and may experience adverse reactions. Overall, sodium benzoate plays a crucial role in ensuring the safety and shelf life of many food and beverage products.

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Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
NMR Spectrum
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: Sodium benzoate

1.2 Synonyms: Benzoic acid sodium salt; Benzoic acid,sodium salt; BENZOTRON(R); Butyryl chloride; EINECS 208-534-8; femanumber3025; MFCD00012463; PUROX S; sobenate; sodium,benzoate; sodiumbenzoate,medicinal; sodiumbenzoicacid; ucephan;

1.3 CAS No.: 532-32-1

1.4 CID: 517055

1.5 EINECS: 208-534-8

1.6 Molecular Formula: C7H5NaO2

1.7 Inchi: InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1

1.8 InChkey: WXMKPNITSTVMEF-UHFFFAOYSA-M

1.9 Canonical Smiles: C1=CC=C(C=C1)C(=O)[O-].[Na+]

1.10 Isomers Smiles: C1=CC=C(C=C1)C(=O)[O-].[Na+]

2. Properties

2.1 Solubility: H2O: 1?M at?20?°C, clear, colorless

2.2 Appearance: White crystalline powder.

2.3 Storage: Aqueous solutions may be sterilized by autoclaving or filtration. The bulk material should be stored in a well-closed container, ina cool, dry place.

2.4 Autoignition Temperature: >500 °C

2.5 Chemical Properties: White crystals or granules, or colorless powder, with sweet astringency. Soluble in water, ethanol, glycerol and methanol.

2.6 Color/Form: White, granules or crystalline powder.
Colorless crystalline powder.

2.7 Decomposition: When heated to decomposition it emits toxic fumes of /sodium oxide/.

2.8 Odor: Odorless

2.9 PH: Aqueous solution is slightly alkaline to litmus, pH about 8

2.10 Water Solubility: soluble

2.11 Spectral Properties: MAX ABSORPTION (ACID (SALT)): 272 NM; 229 NM (A= 761, 1%, 1 CM); (WATER): 225 NM (A= 585, 1%, 1 CM)

2.12 Stability: Stable, but may be moisture senstive. Incompatible with strong oxidizing agents, alkalis, mineral acids.

2.13 StorageTemp: Store at RT.

2.14 Surface Tension: 72.9 mN/m at 20 deg C in water at 1 g/L OECD Guideline 115 (Surface Tension of Aqueous Solutions)

3. Use and Manufacturing

3.1 Definition: ChEBI: An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion.

3.2 Description

Sodium benzoate, with the chemical formula C7H5NaO2, has the CAS number 532-32-1. It appears as a white crystalline powder with no distinct odor. The basic structure of sodium benzoate consists of a benzene ring attached to a carboxyl group and a sodium ion. This compound is highly soluble in water. Sodium benzoate is generally recognized as safe for consumption and is commonly used as a food preservative. However, it may cause allergic reactions in some individuals. In addition, prolonged or excessive exposure to sodium benzoate may have adverse effects on the liver and kidneys. It is important to handle this chemical with care and follow proper safety precautions.

Applicable Fields

Food Preservation: Sodium benzoate is widely used as a preservative in various food and beverage products. Its purpose in this field involves its ability to inhibit the growth of bacteria, yeasts, and molds, thereby extending the shelf life of perishable goods. The mechanism of action in food preservation is based on the ability of sodium benzoate to disrupt the metabolic processes of microorganisms, preventing their growth and proliferation.

Pharmaceuticals: Sodium benzoate is also utilized in the pharmaceutical industry. It is commonly used as a preservative in liquid medications, such as syrups and suspensions, to prevent microbial contamination. The mechanism of action in pharmaceutical applications is similar to that in food preservation, where sodium benzoate inhibits the growth of microorganisms and ensures the safety and stability of the medication.

Storage

Conditions: Store in a cool and dry place.

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3.3 Potential Exposure: Sodium benzoate is used as a food and feed additive, flavor, packaging material; pharmaceutical; preservative for food products and tobacco; anti-fungal agent; antiseptic, rust, and mildew inhibitor; intermediate in the manufacture of dyes. Used as a human hygiene biocidal product.

3.4 Purification Methods: Crystallise it from EtOH (12mL/g). [Beilstein 9 IV 27.]

3.5 Shipping: UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

3.6 Usage: 1. Sodium benzoate is also an important preservative of acid type food. It transforms into effective form of benzoic acid during application. See benzoic acid for application range and dosage. In addition, it also can be used as fodder preservative. 2. Preservatives; antimicrobial agent. 3. Sodium benzoate agent is a very important preservative of acid type fodder. It transforms into effective form of benzoic acid during application. See benzoic acid for application range and dosage. In addition, it also can be used as food preservative. 4. Used in the research of pharmaceutical industry and plant genetic, also used as dye intermediates, fungicide and preservatives. 5. The product is used as food additive (preservative), fungicide in pharmaceutical industry, dye mordant, plasticizer in plastic industrial, and also used as organic synthetic intermediate of spices and others.

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4. Safety and Handling

4.1 Exposure Standards and Regulations: Substance added directly to human food affirmed as generally recognized as safe (GRAS). Current usage results in a max level of 1% in food.
Substances classified as antimycotics, when migrating from food-packaging material shall incl: ... sodium benzoate.
Sodium benzoate used as a chemical preservative at a level not exceeding 1% in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

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4.2 Safety Profile: Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion, intramuscular, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Larger doses of 8-10 g by mouth may cause nausea and vomiting. Small doses have little or no effect. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Na2O. See also BENZOIC ACID.

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4.3 Formulations/Preparations: National Formulary , Food Chemicals Codex dense powder, flake, low dusting dense beverage, granular and technical grades available.
A representative all-purpose hand, face and body lotion prepared with cationic emulsifiers /contains/ 0.125% sodium benzoate.
The amount of sodium benzoate permitted /in fruit juices/ is 0.1 wt% and a common rate of addition to apple juice is 0.05-0.075 wt%.
Ucephan (Kendall-McGaw). Solution (oral) containing 10% each of sodium benzoate and sodium phenylacetate in 100 ml containers.

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4.4 Incompatibilities: Incompatible with quaternary compounds, gelatin, ferric salts,calcium salts, and salts of heavy metals, including silver, lead, andmercury. Preservative activity may be reduced by interactions withkaolin or nonionic surfactants.

4.5 Safety: Safety Information about Sodium benzoate (CAS NO.532-32-1):
Hazard Codes:Xi
Risk Statements:36/37/38-62-63-68
R36/37/38: Irritating to eyes, respiratory system and skin.
R62: Risk of impaired fertility.
R63: Possible risk of harm to the unborn child.
R68: Possible risk of irreversible effects.
Safety Statements:24/25-36-26
S24/25: Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany:1
HS Code:29163100

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4.6 Specification: General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.

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4.7 Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	2gm/kg (2000mg/kg)		FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 34, 1974.
frog	LDLo	subcutaneous	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1313, 1935.
guinea pig	LDLo	intraperitoneal	1400mg/kg (1400mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1313, 1935.
guinea pig	LDLo	subcutaneous	1gm/kg (1000mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 28(1), Pg. 45, 1963.
mouse	LD50	intramuscular	2306mg/kg (2306mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 307, 1956.
mouse	LD50	intravenous	1440mg/kg (1440mg/kg)		Medicinal Chemistry, A Series of Reviews. Vol. 6, Pg. 290, 1963.
mouse	LD50	oral	1600mg/kg (1600mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(1), Pg. 75, 1986.
rabbit	LD50	oral	2gm/kg (2000mg/kg)	?	FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 34, 1974.
rabbit	LD50	subcutaneous	2gm/kg (2000mg/kg)		FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 34, 1974.
rat	LD50	intravenous	1714mg/kg (1714mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 31, Pg. 253, 1942.
rat	LD50	oral	4070mg/kg (4070mg/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 63, 1948.
rat	LD50	subcutaneous	2gm/kg (2000mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 28(1), Pg. 45, 1963.

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5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Eye irritation, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H319 Causes serious eye irritation
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention.
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

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6. NMR Spectrum

13C NMR : Predict

1H NMR : Predict

Predict 1H proton NMR

IR : KBr disc

IR : nujol mull

Raman : 4880 A,200 M,powder

7. Synthesis Route

532-32-1Total: 30 Synthesis Route

93-99-2 29 Suppliers

532-32-1 926 Suppliers

139-02-6 24 Suppliers

614-45-9 80 Suppliers

75-91-2 124 Suppliers

532-32-1 926 Suppliers

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8. Precursor and Product

precursor:

614-34-6

6153-09-9

100-52-7

6935-75-7

5395-00-6

93-99-2

959-22-8

1503-92-0

614-45-9

product:

100-51-6

98-88-4

624-38-4

455-32-3

608-90-2

94-47-3

618-32-6

93-97-0

120-80-9

94-49-5

9. Computed Properties

Molecular Weight：144.10317g/mol
Molecular Formula：C₇H₅NaO₂
Compound Is Canonicalized：True
XLogP3-AA：144.01872368
Monoisotopic Mass：144.01872368
Complexity：108
Rotatable Bond Count：1
Hydrogen Bond Donor Count：0
Hydrogen Bond Acceptor Count：2
Topological Polar Surface Area：40.1
Heavy Atom Count：：10
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：2
CACTVS Substructure Key Fingerprint：AAADcYBgMCAAAAAAAAAAAAAAAAAAAAAAAAAwAAAAAAAAAAABAAAAGgAAAAAADACAmAAwCIAAAACIAiDSCAACAAAkAAAIiAEACMgIJjKAFRCAMQAkwAEIiYeIyCCOAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10.Other Information

Usage: Sodium benzoate is widely used as a preservative in food, medicine, cosmetics and animal feeds. It is used in the treatment of hyperammonemia and urea cycle disorders. It is used in the fireworks as a fuel in whistle mix. It is also used in the preparation of toothpaste and mouthwashes. It finds application in most of the acidic foods such as salad dressings (vinegar), carbonated drinks (carbonic acid), jams and fruit juices (citric acid), pickles (vinegar), and condiments.

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11. Toltal 818 Suppliers View more

Henan Tianfu Chemical Co.,Ltd

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Hebei Saisier Technology Co., LTD

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CAS 532-32-1 additive Sodium benzoate food grade benzoate de sodium powder form with bulk order

Hebei Crovell Biotech Co. Ltd

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CAS No. 532-32-1 Food Preservative Sodium Benzoate

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Sodium benzoate 532-32-1 food grade preservative Price

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12. Related Questions

: What are the potential health risks of consuming sodium benzoate as a food additive? Sodium benzoate is a common food additive used worldwide with the E number E211. It is added to various food and drink products to extend their shelf life. The FDA allows the use of sodium benzoate i..; Why is Sodium Benzoate Polar?Polarity of Sodium benzoate Sodium benzoate exhibits polarity due to the presence of polar covalent bonds between the carbon and oxygen atoms in the carbonyl group (-CO) and the carboxyl group (-COO-)..; Can Sodium Benzoate Replace Other Drugs in Pharmaceutical Applications?Sodium benzoate is a commonly used pharmaceutical ingredient that is widely applied in the field of pharmacy. So, is it possible for sodium benzoate to replace other drugs in pharmaceutical applicatio..; Are Sodium Benzoate and Vitamin C Together a Dangerous Combination?Although there are no studies that definitively demonstrate the dangers of these chemicals, it has been established that sodium benzoate and vitamin C together, when used as a preservative, produce th..

13. Realated Product Infomation