Encyclopedia / Other Inorganic Salts / Cardiovascular Agents / Pharmaceutical Intermediates

Sucrose

CAS：57-50-1
MW:342.3
MF：C12H22O11

White odorless crystalline or powdery solid. Denser than water.

Email Tweet Share

Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
NMR Spectrum
Other Information
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: Sucrose

1.2 Synonyms: amerfand; Amerfond; D(+)-Sucrose; EINECS 200-334-9; Erlotinib-d16 HCl; GNE 410; MFCD00006626; Micr; Microse; SACCHAROSE; SACCHARUM; suc; SUCROSE CONFECTIONERS; SUCROSE SOLUTION; SUCROSE STANDARD; SUGAR; sugar powder; Sugartab; Surose; SWE; α-D-Fructofuranosyl α-D-glucopyranoside; α-D-Glc-(1→2)-Β-D-Fru; α-D-Glucopyranoside, α-D-fructofuranosyl;

View all

1.3 CAS No.: 57-50-1

1.4 CID: 5988

1.5 EINECS: 200-334-9

1.6 Molecular Formula: C12H22O11

1.7 Inchi: InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1

1.8 InChkey: CZMRCDWAGMRECN-UGDNZRGBSA-N

1.9 Canonical Smiles: C(C1C(C(C(C(O1)OC2(C(C(C(O2)CO)O)O)CO)O)O)O)O

1.10 Isomers Smiles: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CO)O)O)CO)O)O)O)O

2. Properties

2.1 Solubility: H2O: 500?mg/mL

2.2 AnalyticLaboratory Methods: SUGARS & SUGAR PRODUCTS BY POLARIMETRIC METHODS.

2.3 Appearance: white crystals or powder

2.4 Storage: Ambient temperatures.

2.5 Chemical Properties: White or almost white, crystalline powder, or lustrous, colourless or white or almost white crystals.

2.6 Color/Form: Powder

2.7 Decomposition: When heated to decomposition it emits acrid smoke and fumes.

2.8 Heat of Combustion: -1.35X10+6 cal/mol

2.9 Odor: Characteristic caramel

2.10 PH: Soln are neutral to litmus

2.11 Physical: SUCROSE; is a white odorless crystalline or powdery solid. Denser than water;.

2.12 pKa: 12.7(at 25℃)

2.13 Water Solubility: 1970 g/L (15 oC)

2.14 Spectral Properties: INDEX OF REFRACTION: 1.5376; SADTLER REFERENCE NUMBER: 8659 (IR, PRISM), 563 (IR, GRATING); SPECIFIC OPTICAL ROTATION: +66.37 @ 20 DEG C/D (WATER)
IR: 3335 (Coblentz Society Spectral Collection)
NMR: 6242 (Sadtler Research Laboratories Spectral Collection)
MASS: 4955 (National Bureau of Standards EPA-NIH Mass Spectra Data Base, NSRDS-NBS-63)

View all

2.15 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. Hydrolyzed by dilute acids and by invertase.

2.16 StorageTemp: Store at RT.

2.17 Surface Tension: 71-75 mN/m @ 1-0.6 mol/l

3. Use and Manufacturing

3.1 Agricultural Uses: is obtained from sugar beet, sugar cane and sweetsorghum. Table sugar is the most common form ofsucrose. It comprises a glucose unit joined to a fructoseunit. Honey consists of sucrose and its hydrolysisproducts. Sucrose, glucose and fructose all exhibit opticalactivity. When sucrose is hydrolyzed, the rotationchanges from right to left. This is called inversion, and anequimolar mixture of glucose and fructose is called invertsugar. The enzyme invertase hydrolyzes sucrose toglucose and fructose. Sugar occurs universally throughout the plantkingdom in fruits, seeds, flowers and roots.

View all

3.2 Definition: ChEBI: Sucrose is a disaccharide formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose.

3.3 Description: Sucrose (CAS 57-50-1) is a common disaccharide that is widely used in various industries. It is a white, crystalline powder with a sweet taste. The basic structure of sucrose consists of glucose and fructose molecules linked together. Sucrose is highly soluble in water, forming a clear solution. It has a melting point of approximately 186 degrees Celsius and a boiling point of 186 degrees Celsius. Chemically, sucrose is a non-reducing sugar and does not undergo the Maillard reaction or caramelization.

Applicable Fields
Food Industry: Sucrose is commonly used as a sweetener in the food industry. It provides sweetness and enhances the flavor of various food products. Sucrose is also used in baking to add volume and texture to baked goods.

Pharmaceutical Industry: Sucrose is used as an excipient in pharmaceutical formulations. It is often used as a filler or bulking agent in tablets and capsules. Sucrose can also be used as a stabilizer in liquid formulations.

Chemical Industry: Sucrose is used as a starting material for the production of various chemicals. It can be hydrolyzed to glucose and fructose, which can then be further processed to produce other chemicals such as ethanol and citric acid.

Mechanism of Action
In the food industry, sucrose acts as a sweetener by stimulating the taste buds on the tongue. It provides a pleasant sweet taste and enhances the flavor of food products. In the pharmaceutical industry, sucrose acts as an excipient by providing bulk and stability to solid and liquid formulations. In the chemical industry, sucrose serves as a starting material for the production of other chemicals through hydrolysis and further processing.

Storage Conditions
Store in a cool, dry place.

View all

3.4 General Description: White odorless crystalline or powdery solid. Denser than water.

3.5 GHS Classification: Signal: Danger
GHS Hazard Statements
Aggregated GHS information provided by 304 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 290 of 304 companies. For more detailed information, please visit ECHA C&L website

Of the 4 notification(s) provided by 14 of 304 companies with hazard statement code(s):

H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
H311 (50%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
H331 (50%): Toxic if inhaled [Danger Acute toxicity, inhalation]
H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H335 (14.29%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H373 (28.57%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H400 (50%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P260, P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P311, P312, P314, P321, P322, P330, P332+P313, P361, P362, P363, P391, P403+P233, P405, and P501

View all

3.6 History: Sucrose is the white granulated compound referred to as sugar. Sucrose is a disaccharide made of glucose and fructose. The main sources of sucrose for the production of commercial sugar are sugarcane and sugar beets. Sugarcane is a tall perennial grass of the genus Saccharum native to Southeast Asia and the South Pacifi c. It has been consumed by chewing the stalk in areas where it grows for thousands of years. Sugarcane spread to India where it was processed to extract crude sugar as early as 2,500 years ago. Persian invaders discovered sugar after invading India and the plant and sugar production spread into the Middle East around 600 c.e. Europeans were introduced to sugar around 1100 c.e. when the first crusaders returned with knowledge of the sweet spice and the Arab Empire spread into Spain.The use of sugar beet to obtain sugar began when the German chemist Andreas Sigismund Marggraf (1709 1782) extracted sucrose from sugar beets using alcohol. The amount of sucrose obtained by Marggraf did not warrant commercial use of beets as a sucrose source. During the late 18th century, Franz Karl Archard (1753 1821), a student of Marggraf, selectively bred beets to increase the sucrose content to 5 6% and developed a commercial method to extract sucrose. Sucrose is predominantly associated with the food industry, but it does have industrial uses in other areas. Sucrose fatty acid esters are a mixture of mono, di, and tri esters of sucrose with fatty acids. Th ese are use in cosmetics, shampoos, resins, inks, paper processing, and pesticides. Sucrose benzoate is used as an emulsifi er and in nail polishes. Sucrose has also been used in making glues and treating leather.

View all

3.7 Methods of Manufacturing: Obtained from sugar cane (Saccharum officinarum L, Gramineae) and sugar beet (Beta valgaris L, Chenopodiaceae). Sugar cane contains from 15-20% and sugar beet form 10-17% sucrose;. Structure: Avery et al, J Chem Soc 1927, 2308; Beevers, Cochrane, Proc Roy Soc 190a, 257 (1947).

3.8 Purification Methods: Crystallise D(+)-sucrose from water (solubility: 1g in 0.5mL H2O at 20o, 1g in 0.2mL in boiling H2O). It is soluble in EtOH (0.6%) and MeOH (1%). Sucrose diacetate hexaisobutyrate is purified by melting and, while molten, treated with NaHCO3 and charcoal, then filtered. [Beilstein 17/8 V 399.]

3.9 Usage: Sucrose (C12H22O11) is one of many forms of sugars (carbohydrates) that are importantorganic compounds for maintaining life.

4. Safety and Handling

4.1 Exposure Standards and Regulations: Substance added directly to human food affirmed as generally recognized as safe (GRAS).

4.2 Octanol/Water Partition Coefficient: log Kow = -3.70

4.3 DisposalMethods: SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

View all

4.4 Fire Fighting Procedures: Water

4.5 Safety Profile: Mildly toxic by ingestion. An experimental teratogen. Mutation data reported. Vigorous reaction with nitric acid or sulfuric acid (forms carbon monoxide and carbon dioxide). When heated to decomposition it emits acrid smoke and irritating fumes.

4.6 Formulations/Preparations: USEPA/OPP Pesticide Code 000023; Trade Names: None.
Grade: Reagent, USP, technical, refined.
Also sold as syrup .. liquid sugar

4.7 Incompatibilities: Powdered sucrose may be contaminated with traces of heavymetals, which can lead to incompatibility with active ingredients,e.g. ascorbic acid. Sucrose may also be contaminated with sulfitefrom the refining process. With high sulfite content, color changescan occur in sugar-coated tablets; for certain colors used in sugarcoatingthe maximum limit for sulfite content, calculated as sulfur, is1 ppm. In the presence of dilute or concentrated acids, sucrose ishydrolyzed or inverted to dextrose and fructose (invert sugar).Sucrose may attack aluminum closures.

View all

4.8 Reactivities and Incompatibilities: Oxidizers, sulfuric acid, nitric acid.

4.9 Report: Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

4.10 Safety: Mildly toxic by ingestion. An experimental teratogen. Mutation data reported. Vigorous reaction with nitric acid or sulfuric acid (forms carbon monoxide and carbon dioxide). When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-37/39-26
S24/25: Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.

View all

4.11 Specification: D(+)-Sucrose , its cas register number is 57-50-1. It also can be called alpha-D-Glucopyranosyl beta-D-fructofuranoside ; beta-D-Fructofuranose-(2-1)-alpha-D-glucopyranoside ; Sucrose ; Saccharose ; and alpha-D-Glucopyranosyl beta-D-fructofuranoside . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: Should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: Wash mouth out with water. Notes to physician: Treat supportively and symptomatically.
In addition, D(+)-Sucrose (CAS NO.57-50-1) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: Carbon monoxide, carbon dioxide.

View all

4.12 Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
domestic animals - goat/sheep	LDLo	oral	40gm/kg (40000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Nutrition Abstracts and Reviews. Vol. 30, Pg. 503, 1960.
mouse	LD50	intraperitoneal	14000mg/kg (14000mg/kg)		Pharmaceutical Chemistry Journal Vol. 15, Pg. 139, 1981.
rat	LD50	oral	29700mg/kg (29700mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Toxicology and Applied Pharmacology. Vol. 7, Pg. 609, 1965.

View all

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s)	No symbol.
Signal word	No signal word.
Hazard statement(s)	none
Precautionary statement(s)
Prevention	none
Response	none
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

View all

6. NMR Spectrum

13C NMR : in D2O

13C NMR : Predict

1H NMR : 400 MHz in D2O

1H NMR : Predict

Predict 1H proton NMR

IR : KBr disc

IR : nujol mull

Mass spectrum (electron ionization)

7. Synthesis Route

57-50-1Total: 53 Synthesis Route

57-48-7 285 Suppliers

57-50-1 349 Suppliers

50-00-0 58 Suppliers

57-50-1 349 Suppliers

View all

8. Precursor and Product

precursor:

470-69-9

141-46-8

470-57-5

50-00-0

512-69-6

470-55-3

99-20-7

126-14-7

57-48-7

product:

96-26-4

56-73-5

77-92-9

97-65-4

56-81-5

78-81-9

56-82-6

69-65-8

57-48-7

67-47-0

9. Computed Properties

Molecular Weight：342.3g/mol
Molecular Formula：C₁₂H₂₂O₁₁
Compound Is Canonicalized：True
XLogP3-AA：342.11621151
Monoisotopic Mass：342.11621151
Complexity：395
Rotatable Bond Count：5
Hydrogen Bond Donor Count：8
Hydrogen Bond Acceptor Count：11
Topological Polar Surface Area：190
Heavy Atom Count：：23
Defined Atom Stereocenter Count：9
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADceBwPAAAAAAAAAAAAAAAAAAAASAAAAAkAAAAAAAAAAAAAAAAGgAACAAACBSwgAMACAAABgAAAAAAAAAAAAAAAAAAAAAAAAAREAIAAAAiQAAFAAAHAAHAYAwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==

10.Other Information

Usage: Used for protein purification in sucrose density gradient studiesSucrose is widely utilized in medications to carry a more pleasant taste to indigestible chemicals. It is used in many medical dosage forms such as chewable tablets, syrups, tablets, or glues. Sucrose is mainly used in foods nowadays. The fatty acid esters of sucrose show useful application in transdermal therapeutic systems. Sucrose-gradient centrifugation also plays an important role in the selective isolation of nocardia spp. from soil.

View all

Usage: Sucrose is widely utilized in medications to carry a more pleasant taste to indigestible chemicals. It is used in many medical dosage forms such as chewable tablets, syrups, tablets, or glues. Sucrose is mainly used in foods nowadays. The fatty acid esters of sucrose show useful application in transdermal therapeutic systems. Sucrose-gradient centrifugation also plays an important role in the selective isolation of nocardia spp. from soil.

View all

Usage: Sucrose is used to prepare density gradients for cell/organelle separation. In addition, sucrose can be used as a supplement in plant, insect, and bacterial culture media. It can also be used in various enzymatic assays. Sucrose is used in molecular biology for the preparation of density gradients.

11. Toltal 330 Suppliers View more

Hebei Danyue Import and Export Co., Ltd

^1YR

Tel: Update Time:2024/11/15

inquire

Factory supply lactose Cas 63-42-3Factory supply sucrose Cas 57-50-1

Tianjin Furun Tongda International Trade Co., LTD

^1YR

Tel: Update Time:2024/11/15

inquire

Factory supply sucrose Cas 57-50-1 from China

Hebei Crovell Biotech Co. Ltd

^1YR

Tel: Update Time:2024/11/15

inquire

Baoji Guokang Healthchem co.,ltd

^1YR

Tel: Update Time:2024/11/15

inquire

High purity Sucrose CAS 57-50-1 with factory price

Wuhan Fortuna Chemical Co., Ltd.

^1YR

Tel: Update Time:2024/08/08

inquire

12. Related Questions

: What are the Chemical Properties and Reactions of Sucrose?Sucrose, also known as α-d-glucopyranosyl-β-d-fructofuranoside, is a disaccharide with the molecular formula C12H22O11. It is primarily found in the cyclic form in solution, with the reactive sites ..; What is Sugar and How is it Used?Sugar is a sweet-tasting, soluble carbohydrate commonly used in food products. Sources and Types Sugars are naturally found in plants, with honey and fruits being common sources of simple sugars. Sucr..; Is Sugar Really a Compound?Sugar, a common ingredient in our daily lives, plays a crucial role in both cooking and biological processes. But what exactly is sugar, and how is it classified? To begin with, it's important to unde..; Where Can You Purchase Sugar Alcohols as Pharmaceutical Raw Materials?Sugar alcohols are sweet-tasting compounds that have lower calories and fewer carbohydrates compared to regular sugars. They are widely used as food additives and sweeteners. There are various types o..

13. Realated Product Infomation