Encyclopedia / Pharmaceutical Intermediates / Organic Intermediate / Pharmaceutical

SULFACHLOROPYRIDAZINE

CAS：80-32-0
MW:284.718
MF：C10H9ClN4O2S

SULFACHLOROPYRIDAZINE, with the chemical formula C10H9ClN4O2S and CAS registry number 80-32-0, is a compound known for its antimicrobial properties. This white crystalline powder is a member of the sulfonamide class of antibiotics and is commonly used in veterinary medicine to treat bacterial infections in animals. Sulfachloropyridazine works by inhibiting the growth of bacteria by interfering with the synthesis of folic acid, an essential nutrient for bacterial survival. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a valuable tool in the fight against bacterial infections. However, it is important to note that the use of sulfachloropyridazine in humans is limited due to the development of resistance and the availability of more effective antibiotics. Overall, sulfachloropyridazine plays a crucial role in veterinary medicine and continues to be an important tool in the treatment of bacterial infections in animals.

View more+

Email Tweet Share

Names and ldentifier
Properties
Use and Manufacturing
Safety and Handling
Msds
Computational chemical data
Realated Product Infomation

1. Names and Identifiers

1.1 Name: SULFACHLOROPYRIDAZINE

1.2 Synonyms: 3-Chloro-6-sulfanilamidopyridazine; 4-Amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide; 6-Sulfanilamido-3-chloropyridazine; AKOS B014357; BA 10370; Bactolin; Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)-; Ciba 10370; Consulid; Cosulid; Durasulf; N1-(6-Chloro-3-pyridazinyl)sulfanilamide; Nefrosul; Nefrosul (TN); Prinz; Renalsulfa; Sonilyn; Soxilyn; Sulfachlorpyridazine; Sulfachlorpyridazine (USP); Sulfaclorazina; Sulfanilamide, N1-(6-chloro-3-pyridazinyl)-; Sulfarene; Sulfochlorpyridazine; Sulphachlorpyridazine; Sulpirazina; VetisullideNefrosul;

View all

1.3 CAS No.: 80-32-0

1.4 CID: 6634

1.5 EINECS: 201-269-9

1.6 Molecular Formula: C10H9ClN4O2S

1.7 Inchi: InChI=1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)

1.8 InChkey: XOXHILFPRYWFOD-UHFFFAOYSA-N

1.9 Canonical Smiles: C1=CC(=CC=C1N)S(=O)(=O)NC2=NN=C(C=C2)Cl

1.10 Isomers Smiles: C1=CC(=CC=C1N)S(=O)(=O)NC2=NN=C(C=C2)Cl

2. Properties

2.1 Solubility: 0.5 M NaOH: soluble50mg/mL

2.2 Storage: 0-6°C

2.3 Color/Form: off-white to light yellow

2.4 pKa: pKa 6.10 (Uncertain)

2.5 Water Solubility: 0.5 M NaOH: soluble50mg/mL

2.6 StorageTemp: 0-6°C

3. Use and Manufacturing

3.1 Definition: ChEBI: A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.

3.2 Description

Sulfachloropyridazine, with the chemical formula C10H9ClN4O2S, has the CAS number 80-32-0. It appears as a white to yellow crystalline powder with a slight odor. The basic structure of sulfachloropyridazine consists of a pyridazine ring attached to a sulfonamide group, which contains a chlorine atom. This compound is sparingly soluble in water. Sulfachloropyridazine is classified as a moderate hazard substance and may cause skin and eye irritation. It is also harmful if swallowed or inhaled. Precautions should be taken to avoid contact with the skin, eyes, and clothing. In case of ingestion, immediate medical attention is required. Sulfachloropyridazine should be handled in a well-ventilated area and with appropriate protective equipment.

Applicable Fields

Veterinary Medicine: Sulfachloropyridazine is commonly used in veterinary medicine as an antibacterial agent. Its mechanism of action involves inhibiting the growth of bacteria by interfering with their ability to synthesize folic acid. This makes it effective in treating various bacterial infections in animals.

Agriculture: Sulfachloropyridazine is also used in agriculture as a pesticide. It acts by inhibiting the growth of bacteria and fungi, thus protecting crops from diseases and improving their yield. Its mechanism of action in this field is similar to its antibacterial activity.

Storage

Conditions: Store in a cool and dry place.

View all

3.3 GHS Classification: Signal: Warning
GHS Hazard Statements
Aggregated GHS information provided by 29 companies from 3 notifications to the ECHA C&L Inventory.

Reported as not meeting GHS hazard criteria by 2 of 29 companies. For more detailed information, please visit ECHA C&L website

Of the 2 notification(s) provided by 27 of 29 companies with hazard statement code(s):

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501

View all

3.4 Usage: Antibacterial compound.

4. Safety and Handling

4.1 Safety: Safety Information of Sulfachlorpyridazine (CAS NO.80-32-0):
Hazard Codes: Xi
Risk Statements: 43
R43:May cause sensitization by skin contact
Safety Statements: 36/37
S36/37:Wear suitable protective clothing and gloves
WGK Germany: 3
When heated to decomposition it emits acrid smoke and irritating fumes.

View all

4.2 Specification: Sulfachlorpyridazine with cas registry number of 80-32-0 is also known as Ba 10370 ; Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)- ; Cluricol ; Durasulf ; N1-(6-Chlor-3-pyridazinyl)sulfanilamid ; N1-(6-Chloro-3-pyridazinyl)sulfanilamide ; Nefrosul ; N(sup 1)-(6-Chloro-3-pyridazinyl)sulfanilamide ; Prinzone vet. ; Sulfachlorpyridazine [USAN:INN] ; Solfaclorpiridazina ; Solfaclorpiridazina [DCIT] ; Sonilyn ; Sulfachlorpyridazinum ; Sulfachlorpyridazinum [INN-Latin] ; Sulfacloropiridazina ; Sulfacloropiridazina [INN-Spanish] ; Sulphachlorpyridazine ; UNII-P78D9P90C0 ; Vetisulid ; Vetisulid (Veterinary) .

View all

5. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Skin sensitization, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H317 May cause an allergic skin reaction
Precautionary statement(s)
Prevention	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse.
Storage	none
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

View all

6. Synthesis Route

80-32-0Total: 3 Synthesis Route

4489-33-2

80-32-0 59 Suppliers

21208-62-8

80-32-0 59 Suppliers

7. Precursor and Product

precursor:

141-30-0

21208-62-8

4489-33-2

63-74-1

product:

5469-69-2

963-14-4

80-35-3

57041-95-9

8. Computed Properties

Molecular Weight：284.718g/mol
Molecular Formula：C₁₀H₉ClN₄O₂S
Compound Is Canonicalized：True
XLogP3-AA：284.0134744
Monoisotopic Mass：284.0134744
Complexity：365
Rotatable Bond Count：3
Hydrogen Bond Donor Count：2
Hydrogen Bond Acceptor Count：6
Topological Polar Surface Area：106
Heavy Atom Count：：18
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：0
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：1
CACTVS Substructure Key Fingerprint：AAADccBzsABEAAAAAAAAAAAAAAAAAAAAAAA8QAAAAAAAAAABwAAAHAYYQAAACAqBUiAx8ZBAAAKiACZiYHDSBBIgBwAcmDgwZpgIIKKBk5GAoABwmAAIyAcQAAAAAAQAAAAAAAAACAAAAAAAAAAAAAAAAA==