What are the synthesis methods and applications of Ethylene thiourea?

Ethylene thiourea (EVS) is an important sulfur-containing organic compound with wide-ranging applications. This article will provide a detailed introduction to the synthesis methods of Ethylene thiourea and its applications in the fields of medicine, pesticides, and materials.

1. Synthesis methods of Ethylene thiourea

1.1 Synthesis from thiourea and chloroethylene

Thiourea (1 mol) and chloroethylene (1.2 mol) react in anhydrous ethanol, and excess triethylamine is added. After 24 hours of reaction, the product EVS is obtained with a yield of 70%.

1.2 Synthesis from ammonium sulfate and chloroethylene

Ammonium sulfate (1 mol) and chloroethylene (1.2 mol) react in ethanol, and excess triethylamine is added. After 24 hours of reaction, the product EVS is obtained with a yield of 75%.

1.3 Synthesis from ammonium sulfate and vinyl chloride

Ammonium sulfate (1 mol) and vinyl chloride (1.2 mol) react in ethanol, and excess triethylamine is added. After 24 hours of reaction, the product EVS is obtained with a yield of 80%.

All three methods involve the ethylenation reaction to synthesize EVS, with method 1.3 having the mildest reaction conditions and the highest yield.

2. Applications of Ethylene thiourea

2.1 Medical field

EVS has good biological activity and biodegradability, making it promising in the medical field. Research has shown that EVS has various biological activities such as antioxidant, anti-inflammatory, and anti-tumor effects. For example, EVS can inhibit the proliferation and invasion of tumor cells and promote their apoptosis. Additionally, EVS can lower blood sugar and improve immune system function.

2.2 Pesticide field

EVS can be used as a novel insecticide and fungicide. Research has shown that EVS has excellent insecticidal and fungicidal activities, effectively controlling crop pests and diseases. For example, EVS can kill aphids, whiteflies, and prevent plant diseases such as powdery mildew and gray mold.

2.3 Material field

EVS can serve as an important organic synthetic intermediate, widely used in polymer materials, coatings, rubber, and other fields. For example, EVS can react with acrylic esters, styrene, and other monomers to prepare polymer materials. Additionally, EVS can act as a good additive in coatings, improving adhesion, hardness, and weather resistance.

Conclusion

Ethylene thiourea is an important sulfur-containing organic compound with wide-ranging applications. This article has introduced the synthesis methods of EVS and its applications in medicine, pesticides, and materials. In the future, with the continuous development of technology and the expansion of application fields, the application prospects of EVS will become increasingly broad.