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What is the Synthesis Process of Palmitoyl Tripeptide-1?

What is the Synthesis Process of Palmitoyl Tripeptide-1?
Fernanda Answered Oct 07 2024

Palmitoyl Oligopeptide underwent a name change in 2013 to distinguish between two distinct molecules developed in 1994. The compounds were renamed as palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl hexapeptide-12 (Pal-KTTKS) to clarify cosmetic product compositions. Palmitoyl tripeptide-1 is a synthetic fatty acid-linked peptide that aids in repairing visible skin damage and strengthening the skin's supportive elements. It acts as a "signal peptide" by instructing the skin to improve its appearance, particularly in reducing signs of sun damage like wrinkles and rough texture.

Palmitoyl Tripeptide-1

Palmitoyl tripeptide-1 consists of the sequence N-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine. Various methodologies have been reported for synthesizing this tripeptide, including EDC-mediated coupling and solid-phase approaches.

Palmitoyl Tripeptide-1

The synthesis of palmitoyl tripeptide-1 involves protecting the carboxylic moiety of Boc-Lys-(Z)-OH, coupling with Boc-His-OH, deprotection/coupling with Boc-Gly-OH, palmitoylation with palmitic acid, and final deprotection of the carboxylic moiety.

References

[1] Diana I S P Resende. “Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.” Pharmaceuticals (2021).

 
N-1(1-oxohexadecyl-glycyl-L-histidyl-L-Lysine
147732-56-7
CAS No:147732-56-7
 
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