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Apramycin sulfate

CAS：41194-16-5
MW:637.65600
MF：C21H43N5O15S

Apramycin sulfate, with the chemical formula C21H41N5O11S and CAS registry number 41194-16-5, is a compound known for its antimicrobial properties. This antibiotic is derived from the bacterium Streptomyces tenebrarius and is commonly used in veterinary medicine to treat bacterial infections in animals. Apramycin sulfate works by inhibiting protein synthesis in bacteria, specifically targeting the 30S ribosomal subunit. It is effective against a wide range of gram-negative bacteria, including Escherichia coli and Salmonella. Apramycin sulfate is not approved for use in humans and is primarily used in livestock and poultry production. It is important to note that the use of antibiotics in animal agriculture raises concerns about the development of antibiotic resistance. Therefore, the responsible use of apramycin sulfate is crucial to mitigate these risks and preserve the effectiveness of this compound for future use.

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Names and ldentifier
Use and Manufacturing
Msds
NMR Spectrum
Computational chemical data
Related Questions
Realated Product Infomation

1. Names and Identifiers

1.1 Name: Apramycin sulfate

1.2 Synonyms: 5-amino-2-({7-amino-6-[(4,6-diamino-2,3-dihydroxycyclohexyl)oxy]-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl}oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol (non-preferred name); 5-AMINO-2-[[9-AMINO-8-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXOXY)-5-HYDROXY-4-METHYLAMINO-2,7-DIOXABICYCLO[4.4.0]DEC-3-YL]OXY]-6-(HYDROXYMETHYL)OXANE-3,4-DIOL; 5-Amino-2-[[9-amino-8-(4,6-diamino-2,3-dihydroxy-cyclohexoxy)-5-hydroxy-4-methylamino-2,7-dioxabicyclo[4.4.0]dec-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4-diol sulfate; 5-Amino-2-[7-amino-6-(4,6-diamino-2,3-dihydroxy-cyclohexyloxy)-4-hydroxy-3-methylamino-octahydro-pyrano[3,2-b]pyran-2-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4-diol; 7-Amino-6-[(4,6-diamino-2,3-dihydroxycyclohexyl)oxy]-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl 4-amino-4-deoxyhexopyranoside; APRAMYCIN SULPHATE; ApramycinSulphateCp2003; NEBRAMYCIN 11 SULPHATE; NEBRAMYCIN II; NEBRAMYCIN II SULFATE;

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1.3 CAS No.: 41194-16-5

1.4 CID: 22008191

1.5 EINECS: 265-890-7

1.6 Molecular Formula: C21H43N5O15S

1.7 Inchi: InChI=1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)

1.8 InChkey: WGLYHYWDYPSNPF-UHFFFAOYSA-N

1.9 Canonical Smiles: CNC1C(C2C(CC(C(O2)OC3C(CC(C(C3O)O)N)N)N)OC1OC4C(C(C(C(O4)CO)N)O)O)O.OS(=O)(=O)O

1.10 Isomers Smiles: CNC1C(C2C(CC(C(O2)OC3C(CC(C(C3O)O)N)N)N)OC1OC4C(C(C(C(O4)CO)N)O)O)O.OS(=O)(=O)O

2. Use and Manufacturing

2.1 Description

Apramycin sulfate, with the chemical formula C21H41N5O11S, has the CAS number 41194-16-5. It appears as a white to off-white powder. It does not have a distinct odor. The basic structure of apramycin sulfate consists of a complex sugar molecule attached to an aminoglycoside antibiotic. This compound is soluble in water. Apramycin sulfate is considered to be harmful if swallowed and may cause irritation to the respiratory system. It is also harmful to aquatic life with long-lasting effects. Therefore, precautions should be taken to prevent its release into the environment.

Applicable Fields

Veterinary Medicine: Apramycin sulfate is commonly used in veterinary medicine as an antibiotic. Its purpose in this field is to treat bacterial infections in animals. The mechanism of action of apramycin sulfate involves inhibiting protein synthesis in bacteria, thereby preventing their growth and replication.

Storage

Conditions: Store in a cool and dry place.

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3. MSDS

2.Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H362 May cause harm to breast-fed children
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention.
Storage	none
Disposal	none

2.3 Other hazards which do not result in classification

none

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4. NMR Spectrum

Predict 1H proton NMR

5. Computed Properties

Molecular Weight：637.65600g/mol
Molecular Formula：C₂₁H₄₃N₅O₁₅S
Compound Is Canonicalized：True
XLogP3-AA：637.24763686
Monoisotopic Mass：637.24763686
Complexity：841
Rotatable Bond Count：6
Hydrogen Bond Donor Count：13
Hydrogen Bond Acceptor Count：20
Topological Polar Surface Area：367
Heavy Atom Count：：42
Defined Atom Stereocenter Count：0
Undefined Atom Stereocenter Count：17
Defined Bond Stereocenter Count：0
Undefined Bond Stereocenter Count：0
Isotope Atom Count：0
Covalently-Bonded Unit Count：2
CACTVS Substructure Key Fingerprint：AAADcfB7vABAAAAAAAAAAAAAAAAAAAAAAAA0SJEAAAAAAACQAAAAHgAQCAAACDzxgAcCCALABoAAAAAAADAAAAAAAAAAAIAIAAATEAIAwAAnQAAHEAAXAAHw8K0AAAAAAAAAAAAAgAAUCACgAAAAAAAAAA==

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Apramycin sulfate Cas 41194-16-5 from China

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7. Related Questions

: What is Apramycin Sulfate and How is it Used in Animal Medicine?Apramycin sulfate, also known as Apramycin sulphate, is a latest-generation aminoglycoside antibiotic specifically developed for animals. It is a new veterinary antibiotic produced by a bacterium call..; What makes Apramycin sulfate an excellent drug for preventing and treating bacterial diarrhea?Currently, there are many drugs available in clinical practice for preventing and treating bacterial diarrhea. These include Amoxicillin, Ciprofloxacin, Enrofloxacin, Neomycin sulfate, Apramycin sulfa..

8. Realated Product Infomation