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Dibenzoylmethane
- CAS:120-46-7
- MW:224.25458
- MF:C15H12O2
yellowish-white powderChEBI: A beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and antica cer effects.
1,3-Diphenyl-1,3-propanedione (dibenzoylmethane, DBM) is an aromatic 1,3-diketone derivative of acetylacetone (acac), where both methyl groups in acac have been substituted by phenyl groups. It is a white solid melting at 77?78°C. Similar to acac, DBM exists in two tautomeric forms, with the keto-enol equilibrium of DBM shifting strongly towards the enol form, particularly in non-polar solvents such as benzene. This is the result of the stability of the intramolecular hydrogen bond in the cis-enol form which is further resonance-stabilized by conjugation with phenyl rings. Due to its high photostability, derivatives of DBM such as avobenzone, have found applications as sunscreen products.
DryPowder; DryPowder, PelletsLargeCrystals; OtherSolid
Dibenzoylmethane is a beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects. It has a role as an antineoplastic agent, a metabolite and an antimutagen. It is a beta-diketone and an aromatic ketone.
Reported in EPA TSCA Inventory.
Hazard Codes:?Xi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25?
S22:Do not breathe dust.?
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: TZ1930000
Hazard Note: Irritant
HS Code: 29143900
Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
?Dibenzoylmethane (CAS NO.120-46-7) is also named as 1,3-Diphenyl-1,3-propanedione ; 2-Benzoylacetophenone ; AI3-19022 ; BRN 0514910 ; CCRIS 8445 ;?Karenzu DK2 ; NSC 6266 ; Phenyl phenacyl ketone ; Rhodiastab 83 ; omega-Benzoylacetophenone?.?Dibenzoylmethane (CAS NO.120-46-7) is?yellowish-white powder. It is easily soluble in alcohol chlorine, chloroform, soluble in sodium hydroxide solution, insoluble in sodium carbonate solution, very slightly soluble in water.
1. | ??? |
orl-rat LD :>500?mg/kg |
??? | NCNSA6 ?? National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. 5 (1953),28. |
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